SynthesisCirculation research2019
Circulating Monocyte Chemoattractant Protein-1 and Risk of Stroke: Meta-Analysis of Population-Based Studies Involving 17 180 Individuals.
Erratum issuedOpen access · greenAbstract readMeta-AnalysisSystematic Review
In one paragraph
Synthesis in Circulation research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 71 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 2 pooled it
4.7field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Circulating Interleukin-6 Levels and Incident Ischemic Stroke: A Systematic Review and Meta-analysis of Prospective Studies.Neurology · 2022Pooled it
- Association of Circulating Monocyte Chemoattractant Protein-1 Levels With Cardiovascular Mortality: A Meta-analysis of Population-Based Studies.JAMA cardiology · 2021Pooled it
- Timing-dependent anti-inflammatory effects of empagliflozin in monocyte-derived macrophages from post-myocardial infarct patients with type 2 diabetes.Cardiovascular diabetology · 2026Trial
- Trial
- Short-term effects of allulose consumption on glucose homeostasis, metabolic parameters, incretin levels, and inflammatory markers in patients with type 2 diabetes: a double-blind, randomized, controlled crossover clinical trial.European journal of nutrition · 2023Trial
- Colchicine Protects Against Sickle Cell Related Cardiomyopathy: Evidence of the Novel Role of Inflammaging.Antioxidants (Basel, Switzerland) · 2026Article
- Mendelian Randomization Analysis of Human Blood Metabolites and Sensorineural Hearing Loss.Brain and behavior · 2026Article
- Targeted plasma proteomics reveals a central role of upregulated TNFRSF proteins in HIV-associated stroke.Nature communications · 2026Article
- Genetic Variation in the Chemokine Network and Atherosclerosis Risk.Current atherosclerosis reports · 2026Review
- HIF-1 Targeting Intervention Renders Protection From Alzheimer's-Like Pathology in a Humanized Mice Model of HIV Infection.Journal of extracellular vesicles · 2025Article
- Obesity-Related Serum Monocyte Chemoattractant Protein-1 (MCP-1) as a Biomarker of Plaque Instability in Patients Undergoing Carotid Endarterectomy.International journal of molecular sciences · 2025Article
- Monocyte Chemoattractant Protein-1 as a Biomarker in Acute Ischemic Stroke: A Prospective Pilot Study.Journal of clinical medicine · 2025Article
- Causal Relationship Between Circulating Inflammatory Cytokines and the Risk of Trigeminal Neuralgia: A Mendelian Randomization Study.Brain and behavior · 2025Article
- Rare damaging CCR2 variants are associated with lower lifetime cardiovascular risk.Genome medicine · 2025Article
- Features of the monocyte inflammatory response in patients with premature coronary artery disease.Biophysics reports · 2025Article
- Emerging biomarkers in ischemic stroke.Vessel plus · 2025Article
- Plasma apolipoprotein E and monocyte chemoattractant protein-1 levels in young people with HIV and ischemic stroke in Lusaka, Zambia.Frontiers in stroke · 2025Article
- Regulatory effects of statins on CCL2/CCR2 axis in cardiovascular diseases: new insight into pleiotropic effects of statins.Journal of inflammation (London, England) · 2024Article
- Molecular Links and Clinical Effects of Inflammation and Metabolic Background on Ischemic Stroke: An Update Review.Journal of clinical medicine · 2024Review
- Monocyte Chemoattractant Protein-1, Inflammatory Biomarkers, and Prognosis of Patients With Ischemic Stroke or Transient Ischemic Attack: Fndings From a Nationwide Registry Study.Journal of the American Heart Association · 2024Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
27 authors at 13 institutions in 5 countries.
Marios K GeorgakisFrom the Institute for Stroke and Dementia Research, University Hospital (M.K.G., R.M., M.D.), Ludwig-Maximilians-University, Munich.
Rainer MalikFrom the Institute for Stroke and Dementia Research, University Hospital (M.K.G., R.M., M.D.), Ludwig-Maximilians-University, Munich.
Harry BjörkbackaClinical Sciences, Malmö, Lund University, Sweden (H.B., G.E., O.M., M.O.-M., A.S., M.S., J.N.).
Tiberiu Alexandru PanaInstitute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Scotland (T.A.P., P.K.M.).
Serkalem DemissieBiostatistics, Boston University School of Public Health, MA (S.D., A.S.B.).
Colby AyersCardiology, University of Texas Southwestern Medical Center, Dallas (C.A., J.A.d.L.).
Mohamed A ElhadadResearch Unit of Molecular Epidemiology (M.A.E.), Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg.
Myriam FornageBrown Foundation Institute of Molecular Medicine, McGovern Medical School and Human Genetics Center, School of Public Health, University of Texas Health Science Center, Houston (M.F.).
Alexa S BeiserBiostatistics, Boston University School of Public Health, MA (S.D., A.S.B.).
Emelia J BenjaminNational Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, MA (S.D., A.S.B., E.J.B., S.S.).
S Matthijs BoekholdtAmsterdam UMC, University of Amsterdam, Cardiology, the Netherlands (M.S.B.).
Gunnar EngströmClinical Sciences, Malmö, Lund University, Sweden (H.B., G.E., O.M., M.O.-M., A.S., M.S., J.N.).
Christian HerderInstitute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf (C.H.).
Ron C HoogeveenMedicine, Baylor College of Medicine, Houston, TX (R.C.H., C.M.B.).
Wolfgang KoenigGerman Research Center for Cardiovascular Disease, Partner site Munich Heart Alliance (M.A.E., W.K.).
Olle MelanderClinical Sciences, Malmö, Lund University, Sweden (H.B., G.E., O.M., M.O.-M., A.S., M.S., J.N.).
Marju Orho-MelanderClinical Sciences, Malmö, Lund University, Sweden (H.B., G.E., O.M., M.O.-M., A.S., M.S., J.N.).
Alexandru SchiopuClinical Sciences, Malmö, Lund University, Sweden (H.B., G.E., O.M., M.O.-M., A.S., M.S., J.N.).
Martin SöderholmClinical Sciences, Malmö, Lund University, Sweden (H.B., G.E., O.M., M.O.-M., A.S., M.S., J.N.).
Nick WarehamMRC Epidemiology Unit, University of Cambridge, United Kingdom (N.W.).
Christie M BallantyneMedicine, Baylor College of Medicine, Houston, TX (R.C.H., C.M.B.).
Annette PetersInstitute of Epidemiology (M.A.E., A.P.), Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg.
Sudha SeshadriNational Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, MA (S.D., A.S.B., E.J.B., S.S.).
Phyo K MyintInstitute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Scotland (T.A.P., P.K.M.).
Jan NilssonClinical Sciences, Malmö, Lund University, Sweden (H.B., G.E., O.M., M.O.-M., A.S., M.S., J.N.).
James A de LemosCardiology, University of Texas Southwestern Medical Center, Dallas (C.A., J.A.d.L.).
Martin DichgansFrom the Institute for Stroke and Dementia Research, University Hospital (M.K.G., R.M., M.D.), Ludwig-Maximilians-University, Munich.
Lund University · SELudwig-Maximilians-Universität München · DEBaylor College of Medicine · USHelmholtz Zentrum München · DENational Heart Lung and Blood Institute · USUniversity of Aberdeen · GBBrown Foundation · USDeutsches Herzzentrum München · DEHeinrich Heine University Düsseldorf · DESouthwestern Medical CenterThe University of Texas Southwestern Medical Center · USUniversity of Amsterdam · NLUniversity of Cambridge · GB
Funding
FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8MUC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI OLICHNEY, JOHN M · 1991 to 2020
$28.3MSouth Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Mohamad Habes · 2021 to 2026
$24.0MPRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9MIDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6MTemporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham CohortsR01AG054076 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DECARLI, CHARLES, SESHADRI, SUDHA · 2016 to 2020
$12.3MTherapeutic target discovery in ADSP data via comprehensive whole-genome analysis incorporating ethnic diversity and systems approachesU01AG058589 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BOERWINKLE, ERIC A., DE JAGER, PHILIP L · 2018 to 2022
$11.1MCognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)RF1AG059421 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SESHADRI, SUDHA · 2018 to 2018
$6.1MFramingham: Inflammation, Genes &Cardiovascular DiseaseR01HL076784 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J. · 2004 to 2008
$3.9MPreclinical AD: Correlates of Amyloid, Tau PET and fcMRI in Framingham Gen 3 Young AdultsR01AG049607 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SESHADRI, SUDHA · 2015 to 2019
$3.1MMicroglial, Inflammatory and Omics Markers of Cerebral Small Vessel Disease in the CHARGE ConsortiumUH3NS100605 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FORNAGE, MYRIAM, SESHADRI, SUDHA · 2018 to 2020
$3.0MCHARGE: Identifying Risk & Protective SNV for AD in ADSP Case-control SampleU01AG049505 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SESHADRI, SUDHA · 2014 to 2017
$3.0MCancer Research UK 14136Medical Research Council G0401527Medical Research Council G0500300Medical Research Council G1000143Medical Research Council MC_UU_12015/1Medical Research Council MR/N003284/1NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS N01 HC025195NHLBI NIH HHS R01 HL076784NHLBI NIH HHS R01 HL092577NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG066546NIA NIH HHS R01 AG028321NIA NIH HHS R01 AG049607NIA NIH HHS R01 AG054076NIA NIH HHS RF1 AG059421NIA NIH HHS U01 AG049505NIA NIH HHS U01 AG052409NIA NIH HHS U01 AG058589NINDS NIH HHS R01 NS017950NINDS NIH HHS R01 NS087541NINDS NIH HHS UH2 NS100605NINDS NIH HHS UH3 NS100605
Abstract
PubMed holds no abstract for this paper.
Indexed as
AdultAgedAtherosclerosisBiomarkersChemokine CCL2FemaleHumansMaleMiddle AgedStrokeBiomarkersCCL2 protein, humanChemokine CCL2atherosclerosiscerebrovascular disorderschemokine CCL2inflammationstroke
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.