ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2019
Accelerated cortical thinning within structural brain networks is associated with irritability in youth.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? - a systematic review.Journal of child psychology and psychiatry, and allied disciplines · 2025Pooled it
- Taming dimensionality in big neuroimaging data: Efficient orthonormal projective NMF via stochastic learning and data compression.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Concurrent and longitudinal neurostructural correlates of irritability in children.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Neural mechanisms of inhibitory control in preadolescent irritability: Insights from the ABCD study.Biological psychology · 2024Article
- An Expanded Conceptual Framework for Understanding Irritability in Childhood: The Role of Cognitive Control Processes.Clinical child and family psychology review · 2024Review
- Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Reduced grey matter volume in adolescents with conduct disorder: a region-of-interest analysis using multivariate generalized linear modeling.Discover mental health · 2023Article
- Reduced Grey Matter Volume in Adolescents with Conduct Disorder: A Region-of-Interest Analysis Using Multivariate Generalized Linear Modeling.Research square · 2023Article
- Leveraging genetic overlap between irritability and psychiatric disorders to identify genetic variants of major psychiatric disorders.Experimental & molecular medicine · 2023Article
- Conduct problems are associated with accelerated thinning of emotion-related cortical regions in a community-based sample of adolescents.Psychiatry research. Neuroimaging · 2023Article
- Developmental patterning of irritability enhances prediction of psychopathology in preadolescence: Improving RDoC with developmental science.Journal of psychopathology and clinical science · 2022Article
- Mobile footprinting: linking individual distinctiveness in mobility patterns to mood, sleep, and brain functional connectivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Network-wise surface-based morphometric insight into the cortical neural circuitry underlying irritability in adolescents.Translational psychiatry · 2021Article
- Sleep and longitudinal cognitive performance in preclinical and early symptomatic Alzheimer's disease.Brain : a journal of neurology · 2021Article
- Linking irritability and functional brain networks: A transdiagnostic case for expanding consideration of development and environment in RDoC.Neuroscience and biobehavioral reviews · 2021Review
- Structural atrophy of the right superior frontal gyrus in adolescents with severe irritability.Human brain mapping · 2021Article
- Morphological integration of the human brain across adolescence and adulthood.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Irritability Is Associated With Decreased Cortical Surface Area and Anxiety With Decreased Gyrification During Brain Development.Frontiers in psychiatry · 2021Article
- Structural brain networks in remitted psychotic depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Longitudinal Development of Brain Iron Is Linked to Cognition in Youth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
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Authors and funding
23 authors.
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Abstract
Irritability is an important dimension of psychopathology that spans multiple clinical diagnostic categories, yet its relationship to patterns of brain development remains sparsely explored. Here, we examined how transdiagnostic symptoms of irritability relate to the development of structural brain networks. All participants (n = 137, 83 females) completed structural brain imaging with 3 Tesla MRI at two timepoints (mean age at follow-up: 21.1 years, mean inter-scan interval: 5.2 years). Irritability at follow-up was assessed using the Affective Reactivity Index, and cortical thickness was quantified using Advanced Normalization Tools software. Structural covariance networks were delineated using non-negative matrix factorization, a multivariate analysis technique. Both cross-sectional and longitudinal associations with irritability at follow-up were evaluated using generalized additive models with penalized splines. The False Discovery Rate (q < 0.05) was used to correct for multiple comparisons. Cross-sectional analysis of follow-up data revealed that 11 of the 24 covariance networks were associated with irritability, with higher levels of irritability being associated with thinner cortex. Longitudinal analyses further revealed that accelerated cortical thinning within nine networks was related to irritability at follow-up. Effects were particularly prominent in brain regions implicated in emotion regulation, including the orbitofrontal, lateral temporal, and medial temporal cortex. Collectively, these findings suggest that irritability is associated with widespread reductions in cortical thickness and accelerated cortical thinning, particularly within the frontal and temporal cortex. Aberrant structural maturation of regions important for emotional regulation may in part underlie symptoms of irritability.
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