ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2019
Genome-wide association studies identify polygenic effects for completed suicide in the Japanese population.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 5 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 5 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Japanese Cohort Study Identifies an Association Between the Serotonin Transporter-Linked Polymorphic Region and Suicide Death.Neuropsychopharmacology reports · 2026Pooled it
- Increased somatic mosaicism in autosomal and X chromosomes for suicide death.Molecular psychiatry · 2025Pooled it
- Association of two variable number of tandem repeats in the monoamine oxidase A gene promoter with suicide completion: The present study and meta-analysis.Neuropsychopharmacology reports · 2023Pooled it
- Genome-wide association study meta-analysis of suicide death and suicidal behavior.Molecular psychiatry · 2023Pooled it
- Genetics and epigenetics of self-injurious thoughts and behaviors: Systematic review of the suicide literature and methodological considerations.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2022Pooled it
- Pursuing the elusive biosignature for suicide: a decennial update.Molecular psychiatry · 2026Review
- Article
- Epigenetics and immunology: Under-recognized aspects of suicidality.World journal of psychiatry · 2025Review
- Genomic links between symptoms of eating disorders and suicidal ideation.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- A network frame offers a promising transdisciplinary tool for understanding complex health and health care system problems like suicide.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Using the Strategy of Genome-Wide Association Studies to Identify Genetic Markers of Suicidal Behavior: A Narrative Review.Consortium psychiatricum · 2024Review
- Biological Factors Underpinning Suicidal Behaviour: An Update.Brain sciences · 2023Review
- A population-wide analysis of the familial risk of suicide in Utah, USA.Psychological medicine · 2023Article
- Identification of potential blood biomarkers associated with suicide in major depressive disorder.Translational psychiatry · 2022Article
- Extended familial risk of suicide death is associated with younger age at death and elevated polygenic risk of suicide.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2022Article
- Dissecting the genetic architecture of suicide attempt and repeated attempts in Korean patients with bipolar disorder using polygenic risk scores.International journal of bipolar disorders · 2022Article
- Association of Genome-Wide Polygenic Scores for Multiple Psychiatric and Common Traits in Preadolescent Youths at Risk of Suicide.JAMA network open · 2022Article
- College students' screening early warning factors in identification of suicide risk.Frontiers in genetics · 2022Article
- Neurexin 1 variants as risk factors for suicide death.Molecular psychiatry · 2021Article
- 'Omics' of suicidal behaviour: A path to personalised psychiatry.World journal of psychiatry · 2021Review
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Suicide is a significant public health problem worldwide, and several Asian countries including Japan have relatively high suicide rates on a world scale. Twin, family, and adoption studies have suggested high heritability for suicide, but genetics lags behind due to difficulty in obtaining samples from individuals who died by suicide, especially in non-European populations. In this study, we carried out genome-wide association studies combining two independent datasets totaling 746 suicides and 14,049 non-suicide controls in the Japanese population. Although we identified no genome-wide significant single-nucleotide polymorphisms (SNPs), we demonstrated significant SNP-based heritability (35-48%; P < 0.001) for completed suicide by genomic restricted maximum-likelihood analysis and a shared genetic risk between two datasets (P
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.