ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2019
Ventral pallidum is essential for cocaine relapse after voluntary abstinence in rats.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed.
- Unpacking Ventral Pallidum GABA Neuron Contributions to Opioid Drug Reward in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Ventral pallidum GABA neuron inhibition augments context-appropriate defensive responses to learned threat cues.Neurobiology of stress · 2026Article
- Sex differences in stress-modulated cocaine vulnerability: female rodents are more sensitive to the effects of stress exposure at different developmental stages.Frontiers in behavioral neuroscience · 2025Review
- Transcriptomic landscape of mammalian ventral pallidum at single-cell resolution.Science advances · 2024Article
- Sex differences in sensitivity to dopamine receptor manipulations of risk-based decision making in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Pavlovian cue-evoked alcohol seeking is disrupted by ventral pallidal inhibition.Addiction neuroscience · 2024Article
- Parvalbumin expression does not account for discrete electrophysiological profiles of glutamatergic ventral pallidal subpopulations.Addiction neuroscience · 2024Article
- Sex differences in the structure and function of the vasopressin system in the ventral pallidum are associated with the sex-specific regulation of social play behavior in juvenile rats.Hormones and behavior · 2024Article
- Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types.Nature communications · 2024Article
- Pavlovian cue-evoked alcohol seeking is disrupted by ventral pallidal inhibition.bioRxiv : the preprint server for biology · 2024Article
- A head-to-head comparison of two DREADD agonists for suppressing operant behavior in rats via VTA dopamine neuron inhibition.Psychopharmacology · 2023Article
- Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types.bioRxiv : the preprint server for biology · 2023Article
- A head-to-head comparison of two DREADD agonists for suppressing operant behavior in rats via VTA dopamine neuron inhibition.bioRxiv : the preprint server for biology · 2023Article
- Oral oxycodone self-administration leads to features of opioid misuse in male and female mice.Addiction biology · 2023Article
- Astrocyte regulation of synaptic signaling in psychiatric disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Ventral pallidal regulation of motivated behaviors and reinforcement.Frontiers in neural circuits · 2023Review
- Individual differences in cocaine seeking during voluntary abstinence predicts cocaine relapse and the circuitry mediating relapse.Psychopharmacology · 2022Article
- Sign-tracking modulates reward-related neural activation to reward cues, but not reward feedback.The European journal of neuroscience · 2022Article
- Ventral pallidum GABA neurons bidirectionally control opioid relapse across rat behavioral models.Addiction neuroscience · 2022Article
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Abstract
Addiction is a chronic relapsing disorder, and during recovery many people experience several relapse events as they attempt to voluntarily abstain from drug. New preclinical relapse models have emerged that capture this common human experience, and mounting evidence indicates that resumption of drug seeking after voluntary abstinence recruits neural circuits distinct from those recruited during reinstatement after experimenter-imposed abstinence, or abstinence due to extinction training. Ventral pallidum (VP), a key limbic node involved in drug seeking, has well-established roles in conventional reinstatement models tested following extinction training, but it is unclear whether this region also participates in more translationally relevant models of relapse. Here we show that chemogenetic inhibition of VP neurons decreased cocaine-, context-, and cue-induced relapse tested after voluntary, punishment-induced abstinence. This effect was strongest in the most compulsive, punishment-resistant rats, and reinstatement was associated with neural activity in anatomically defined VP subregions. VP inhibition also attenuated the propensity of rats to display "abortive lever pressing," a species-typical risk assessment behavior seen here during punished drug taking, likely resulting from concurrent approach and avoidance motivations. These results indicate that VP, unlike other connected limbic brain regions, is essential for resumption of drug seeking after voluntary abstinence. Since VP inhibition effects were strongest in the most compulsively cocaine-seeking individuals, this may also indicate that VP plays a particularly important role in the most pathological, addiction-like behavior, making it an attractive target for future therapeutic interventions.
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