Evidence map›Paper›PMID 31476365›Full record

ReviewFree radical biology & medicine2019

Epitranscriptomic systems regulate the translation of reactive oxygen species detoxifying and disease linked selenoproteins.

Andrea Leonardi, Sara Evke, May Lee, J Andres Melendez, Thomas J Begley

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Free radical biology & medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. tRNA modification enzyme-dependent redox homeostasis regulates synapse formation and memory.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Review
  6. Article
  7. Article
  8. Selenoproteins and the senescence-associated epitranscriptome.Experimental biology and medicine (Maywood, N.J.) · 2022
    Review
  9. Review
  10. Arsenite toxicity is regulated by queuine availability and oxidation-induced reprogramming of the human tRNA epitranscriptome.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Andrea LeonardiColleges of Nanoscale Science and Engineering, University at Albany, State University of New York, Albany, NY, USA.
Sara EvkeColleges of Nanoscale Science and Engineering, State University of New York Polytechnic Institute, Albany, NY, USA.
May LeeColleges of Nanoscale Science and Engineering, State University of New York Polytechnic Institute, Albany, NY, USA.
J Andres MelendezColleges of Nanoscale Science and Engineering, State University of New York Polytechnic Institute, Albany, NY, USA. Electronic address: jmelendez@sunypoly.edu.
Thomas J BegleyDepartment of Biological Sciences, University at Albany, State University of New York, Albany, NY, USA; RNA Institute, University at Albany, State University of New York, Albany, NY, USA. Electronic address: tbegley@albany.edu.
SUNY Polytechnic Institute · USAlbany State University · US

Funding

Translational regulation in exposure biology: Xenobiotic-induced reprograming oftRNA modifications and selective translation of codon-biased response genes in rat and humanmodelsR01ES026856 · NIEHS · SUNY POLYTECHNIC INSTITUTE · PI Thomas J Begley, Peter C Dedon · 2016 to 2026
$3.9M
Translational Control of ROS ManagementR01ES024615 · NIEHS · SUNY POLYTECHNIC INSTITUTE · PI BEGLEY, THOMAS J · 2014 to 2018
$1.8M
NIEHS NIH HHS R01 ES024615NIEHS NIH HHS R01 ES026856
6 · The paper itself

Abstract

Here we highlight the role of epitranscriptomic systems in post-transcriptional regulation, with a specific focus on RNA modifying writers required for the incorporation of the 21st amino acid selenocysteine during translation, and the pathologies linked to epitranscriptomic and selenoprotein defects. Epitranscriptomic marks in the form of enzyme-catalyzed modifications to RNA have been shown to be important signals regulating translation, with defects linked to altered development, intellectual impairment, and cancer. Modifications to rRNA, mRNA and tRNA can affect their structure and function, while the levels of these dynamic tRNA-specific epitranscriptomic marks are stress-regulated to control translation. The tRNA for selenocysteine contains five distinct epitranscriptomic marks and the ALKBH8 writer for the wobble uridine (U) has been shown to be vital for the translation of the glutathione peroxidase (GPX) and thioredoxin reductase (TRXR) family of selenoproteins. The reactive oxygen species (ROS) detoxifying selenocysteine containing proteins are a prime examples of how specialized translation can be regulated by specific tRNA modifications working in conjunction with distinct codon usage patterns, RNA binding proteins and specific 3' untranslated region (UTR) signals. We highlight the important role of selenoproteins in detoxifying ROS and provide details on how epitranscriptomic marks and selenoproteins can play key roles in and maintaining mitochondrial function and preventing disease.

Indexed as

Epigenesis, GeneticRNA Processing, Post-TranscriptionalTranscriptomeAnimalsDiseaseHumansOxidation-ReductionProtein BiosynthesisReactive Oxygen SpeciesSeleniumSelenoproteinsSignal TransductionReactive Oxygen SpeciesSeleniumSelenoproteins

Identifiers

PMID31476365
PMCPMC7650020
OpenAlexW2971134501

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.