ArticleJournal of Alzheimer's disease : JAD2019
Association Between Cardiovascular Health and Cognitive Performance: A Twins Study.
Article in Journal of Alzheimer's disease : JAD, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cardiovascular Health, 2010 to 2020: A Systematic Review of a Decade of Research on Life's Simple 7.Journal of the American Heart Association · 2025Pooled it
- Pooled it
- Increasing cardiovascular disease risk predicts faster cognitive decline: A Bayesian analysis of a cohort of adults in rural West Texas.The journal of prevention of Alzheimer's disease · 2026Article
- Circulating Progenitor Cells, Regenerative Capacity and Cognition: Evidence From 2 Community-Based Cohorts.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- Association of neighborhood and individual-level socioeconomic disadvantage in childhood and adulthood with cognitive function in mid-adulthood: Cardiovascular Risk in Young Finns Study.American journal of epidemiology · 2026Article
- Pure tone auditory thresholds and their association with cognition in the Canadian Longitudinal Study on Aging.Scientific reports · 2026Article
- Persistent financial adversity and cognitive aging: a life course investigation.Innovation in aging · 2026Article
- A multilevel conceptual framework for dementia: from life-course mechanisms to public health strategies.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026Review
- Do music-related leisure activities influence cardiovascular disease risk, blood pressure and heart rate in older adults?International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Assessment of Risk Factors for Cognitive Impairment Accounting for Genetic and Environmental Influences: An Italian Population-Based Twin Study.Brain sciences · 2025Article
- Brain-derived 5-hydroxymethylcytosine epigenetic scores are related to Alzheimer's disease pathology and cognitive decline.Acta neuropathologica · 2025Article
- Microcardia and cardiomegaly screening using postero-anterior chest X-ray (PA CXR) across university students in Ghana - a retrospective study.BMC medical imaging · 2024Article
- Cardiovascular health ("Life's Essential 8"), risk of depression and anxiety: a prospective cohort study.NPJ cardiovascular health · 2024Article
- Change in cardiovascular health and rate of cognitive decline in older adults: a 15-year population-based study.BMC geriatrics · 2024Article
- Progesterone Receptor Membrane Component 1 Regulates Cellular Stress Responses and Inflammatory Pathways in Chronic Neuroinflammatory Conditions.Antioxidants (Basel, Switzerland) · 2024Article
- Association of cardiovascular health with cognitive function and the mediating effect of depressive state.Frontiers in aging neuroscience · 2024Article
- Examining Demographic Factors, Psychosocial Wellbeing and Cardiovascular Health in Subjective Cognitive Decline in the Brain Health Registry Cohort.The journal of prevention of Alzheimer's disease · 2024Article
- Understanding factors associated with the trajectory of subjective cognitive complaints in groups with similar objective cognitive trajectories.Alzheimer's research & therapy · 2023Article
- Associations Between Traumatic Brain Injury and Cognitive Decline Among Older Male Veterans: A Twin Study.Neurology · 2023Article
- Effects of Physical Activity in the High School Curriculum on Cardiovascular Health, Cognitive and Physical Performance.Journal of functional morphology and kinesiology · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
BACKGROUND/
objectiveThe 2020 Strategic Impact Goal introduced by the American Heart Association (AHA) aims at improving cardiovascular health (CVH) of all Americans by 20%. AHA defined ideal CVH across seven established modifiable risk factors for cardiovascular diseases. Prior studies have indicated that ideal CVH also benefits brain health and cognitive aging, but it is possible that this association is explained by familial factors.
methodsWe examined 272 male monozygotic and dizygotic twin pairs (total 544 subjects) free of overt cardiovascular disease and dementia from the Vietnam Era Twin Registry. Memory and learning were measured by Trail Making tests and Wechsler Memory Scale (Immediate and Delayed Memory tests and Visual Reproductive Test). Each of the seven CVH components (smoking, body mass index, physical activity, diet, total cholesterol, blood pressure, and blood glucose) was scored per established criterion.
resultsThe mean age of the twins was 55 years, 96% were whites, and 61% monozygotic. When considering twins as individuals, for every unit increase in CVH score (indicating better cardiovascular health), twins demonstrated faster cognitive processing speed (Trail B: - 5.6 s, 95% CI - 10.3, - 0.9; p = 0.03) and better story recall, both immediate (0.35, 95% CI 0.06, 0.62; p = 0.02) and delayed (0.39, 95% CI 0.08, 0.70; p = 0.01).
conclusionsBetter CVH is associated with better cognitive health in several domains. As suggested by within-pair analysis, this association is largely explained by familial factors, implying that early life exposures are shared determinants of both brain health and cardiovascular health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.