ArticleJournal of chemical theory and computation2019
Surface Shear Viscosity and Interleaflet Friction from Nonequilibrium Simulations of Lipid Bilayers.
Article in Journal of chemical theory and computation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 49 citations in OpenAlex.
- Antigen mobility regulates the dynamics and precision of antigen capture in the B cell immune synapse.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Effects of a Polarizable Force Field on Membrane Dynamics: Surface Viscosity, Lipid Diffusion, and Peptide Induced Pore Formation.Journal of computational chemistry · 2025Article
- Phonons reveal coupled cholesterol-lipid dynamics in ternary membranes.Biophysical journal · 2024Article
- Curvature fluctuations of fluid vesicles reveal hydrodynamic dissipation within the bilayer.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- O-glycans Expand Lubricin and Attenuate Its Viscosity and Shear Thinning.Biomacromolecules · 2024Article
- Metastable States in the Hinge-Bending Landscape of an Enzyme in an Atomistic Cytoplasm Simulation.The journal of physical chemistry letters · 2024Article
- Protein Crowding and Cholesterol Increase Cell Membrane Viscosity in a Temperature Dependent Manner.Journal of chemical theory and computation · 2023Article
- Kinetic relaxation of giant vesicles validates diffusional softening in a binary lipid mixture.Physical review. E · 2023Article
- Surface viscosities of lipid bilayers determined from equilibrium molecular dynamics simulations.Biophysical journal · 2023Article
- Molecular simulations and NMR reveal how lipid fluctuations affect membrane mechanics.Biophysical journal · 2023Article
- Systematic measurements of interleaflet friction in supported bilayers.Biophysical journal · 2022Article
- A vesicle microrheometer for high-throughput viscosity measurements of lipid and polymer membranes.Biophysical journal · 2022Article
- Article
- Mechanical properties of anionic asymmetric bilayers from atomistic simulations.The Journal of chemical physics · 2021Article
- CHARMM36 Lipid Force Field with Explicit Treatment of Long-Range Dispersion: Parametrization and Validation for Phosphatidylethanolamine, Phosphatidylglycerol, and Ether Lipids.Journal of chemical theory and computation · 2021Article
- Large-scale simulation of biomembranes incorporating realistic kinetics into coarse-grained models.Nature communications · 2020Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Nonequilibrium simulation protocols based on shear deformations are applied to determine the surface viscosity and interleaflet friction of lipid bilayers. At high shear rates, a non-Newtonian shear thinning regime is observed, but lower shear rates yield a Newtonian plateau and results that are consistent with equilibrium measurements based on fluctuation-dissipation theorems. Application to all-atom bilayers modeled with the CHARMM36 parameter set yields values for the surface viscosity that are consistent with microscopic measurements based on membrane protein diffusion but are approximately 10 times lower than more macroscopic experimental measurements. The interleaflet friction is about 10 times lower than experimental measurements. Trends across different lipids, temperatures, and ternary liquid-disordered phase mixtures produce results that are consistent with experimental diffusion constants. Application of the protocol to the liquid-ordered phase fails to yield a Newtonian plateau, suggesting more complex rheology.
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