Evidence map›Paper›PMID 31476020›Full record

ArticleBritish journal of pharmacology2020

Bronchodilation induced by PGE

Gulsev Ozen, Chabha Benyahia, Salma Mani, Kamel Boukais, Adam M Silverstein, Richard Bayles, Andrew C Nelsen, Yves Castier, Claire Danel, Hervé Mal and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in British journal of pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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  7. Bronchodilation induced by PGEBritish journal of pharmacology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 5 countries.

Gulsev OzenINSERM U1148, Hôpital Bichat, Paris, France.
Chabha BenyahiaINSERM U1148, Hôpital Bichat, Paris, France.
Salma ManiINSERM U1148, Hôpital Bichat, Paris, France.
Kamel BoukaisINSERM U1148, Hôpital Bichat, Paris, France.
Adam M SilversteinUnited Therapeutics, Research Triangle Park, NC, USA.
Richard BaylesINSERM U1148, Hôpital Bichat, Paris, France.
Andrew C NelsenUnited Therapeutics, Research Triangle Park, NC, USA.
Yves CastierHôpital Bichat-Claude Bernard, AP-HP, Paris Diderot University, Université de Paris, Paris, France.
Claire DanelHôpital Bichat-Claude Bernard, AP-HP, Paris Diderot University, Université de Paris, Paris, France.
Hervé MalHôpital Bichat-Claude Bernard, AP-HP, Paris Diderot University, Université de Paris, Paris, France.
Lucie H ClappInstitute of Cardiovascular Science, University College London, London, UK.
Dan LongroisINSERM U1148, Hôpital Bichat, Paris, France.
Xavier NorelINSERM U1148, Hôpital Bichat, Paris, France.ORCID 0000-0003-0734-3359
Inserm · FRUniversité Claude Bernard Lyon 1 · FRTriangle · USUniversity College London · GB

Funding

United Therapeutics Corporation
6 · The paper itself

Abstract

background and purposeIn patients with pulmonary hypertension (PH) associated with lung disease and/or hypoxia (Group III), decreased pulmonary vascular tone and tissue hypoxia is therapeutically beneficial. PGE EXPERIMENTAL APPROACH: Relaxation of bronchial muscle was assessed in samples isolated from control and PH Group III patients. Expression of prostanoid receptors was analysed by western blot and real-time PCR, and endogenous PGE KEY

resultsMaximal relaxations induced by different EP CONCLUSION AND IMPLICATIONS: The PGI

Indexed as

AdultAgedAged, 80 and overAntihypertensive AgentsBronchiBronchodilator AgentsDinoprostoneDose-Response Relationship, DrugEpoprostenolFemaleHumansHypertension, PulmonaryIloprostMaleMiddle AgedOrgan Culture TechniquesAntihypertensive AgentsBronchodilator AgentsDinoprostoneEpoprostenolIloprostL-902688PyrrolidinonesReceptors, Prostaglandin E, EP4 SubtypeTetrazolestreprostinilVasodilator Agents

Identifiers

PMID31476020
PMCPMC6976782
OpenAlexW2972203346

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.