ArticleJournal of musculoskeletal & neuronal interactions2019
Myostatin dysfunction does not protect from fasting-induced loss of muscle mass in mice.
Article in Journal of musculoskeletal & neuronal interactions, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed.
- From twitch to relaxation: Obesity dysregulates muscle contractile function.Physiological reports · 2026Article
- Metabolic stress and muscle mechanics: Acute response of isolated soleus and EDL muscles to prolonged fasting in mice with distinct muscle phenotypes.Biology open · 2025Article
- Obesity-driven musculotendinous remodeling impairs tissue resilience to mechanical damage.Cell and tissue research · 2025Article
- Caloric RestrictionNutrients · 2021Article
- P38α-MAPK Signaling Inhibition Attenuates Soleus Atrophy during Early Stages of Muscle Unloading.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of the study was to investigate if myostatin dysfunction can ameliorate fasting-induced muscle wasting.
methods18-week old males from Berlin high (BEH) strain with myostatin dysfunction and wild type myostatin (BEH+/+) strain were subjected to 48-h food deprivation (FD). Changes in body composition as well as contractile properties of soleus (SOL) and extensor digitorum longus (EDL) muscles were studied.
resultsBEH mice were heavier than BEH+/+ mice (56.0±2.5 vs. 49.9±2.8 g, P<0.001, respectively). FD induced similar loss of body mass in BEH and BEH+/+ mice (16.6±2.4 vs. 17.4±2.2%, P>0.05), but only BEH mice experienced wasting of the gastrocnemius, tibialis anterior and plantaris muscles. FD induced a marked decrease in specific muscle force of SOL. EDL of BEH mice tended to be protected from this decline.
conclusionMyostatin dysfunction does not protect from loss of muscle mass during fasting.
Indexed as
Identifiers
31475942PMC6737554What OpenQuestion holds
Registered trials
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