Evidence map›Paper›PMID 31475925›Full record

ArticleActa crystallographica. Section F, Structural biology communications2019

Structure of GTP cyclohydrolase I from Listeria monocytogenes, a potential anti-infective drug target.

Sonja Schüssler, Ilka Haase, Markus Perbandt, Boris Illarionov, Alexandra Siemens, Klaus Richter, Adelbert Bacher, Markus Fischer, Tobias Gräwert

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta crystallographica. Section F, Structural biology communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Sonja SchüsslerHamburg School of Food Science, Universität Hamburg, Grindelallee 117, 20146 Hamburg, Germany.
Ilka HaaseHamburg School of Food Science, Universität Hamburg, Grindelallee 117, 20146 Hamburg, Germany.
Markus PerbandtInstitute for Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, Universität Hamburg, Notkestrasse 85, 22607 Hamburg, Germany.
Boris IllarionovHamburg School of Food Science, Universität Hamburg, Grindelallee 117, 20146 Hamburg, Germany.
Alexandra SiemensHamburg School of Food Science, Universität Hamburg, Grindelallee 117, 20146 Hamburg, Germany.
Klaus RichterDepartment of Chemistry, Technical University of Munich, Lichtenbergstrasse 4, 85748 Garching, Germany.
Adelbert BacherHamburg School of Food Science, Universität Hamburg, Grindelallee 117, 20146 Hamburg, Germany.
Markus FischerHamburg School of Food Science, Universität Hamburg, Grindelallee 117, 20146 Hamburg, Germany.
Tobias GräwertHamburg School of Food Science, Universität Hamburg, Grindelallee 117, 20146 Hamburg, Germany.
Universität Hamburg · DEMSH Medical School Hamburg – University of Applied Sciences and Medical University · DEMax Planck Institute for the Structure and Dynamics of Matter · DETechnical University of Munich · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A putative open reading frame encoding GTP cyclohydrolase I from Listeria monocytogenes was expressed in a recombinant Escherichia coli strain. The recombinant protein was purified and was confirmed to convert GTP to dihydroneopterin triphosphate (K

Indexed as

Anti-Bacterial AgentsBacterial ProteinsCrystallography, X-RayEscherichia coliGTP CyclohydrolaseListeria monocytogenesNeopterinProtein ConformationRecombinant ProteinsSmall Molecule LibrariesAnti-Bacterial AgentsBacterial Proteinsdihydroneopterin triphosphateGTP CyclohydrolaseNeopterinRecombinant ProteinsSmall Molecule Librariescrystal structureGTP cyclohydrolase Ihigh-throughput screeningListeria monocytogeneslisteriosistetrahydrofolate biosynthesis

Identifiers

PMID31475925
PMCPMC6718149
OpenAlexW2970582521

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.