Evidence map›Paper›PMID 31475862›Full record

ArticleEuropean journal of preventive cardiology2020

Familial occurrence of mitral regurgitation in patients with mitral valve prolapse undergoing mitral valve surgery.

Yasmine L Hiemstra, Aniek L van Wijngaarden, Mathilde W Bos, Martin J Schalij, Robert Jm Klautz, Jeroen J Bax, Victoria Delgado, Daniela Qcm Barge-Schaapveld, Nina Ajmone Marsan

Abstract readComparative Study
PubMed Full text at PMC Publisher
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Article in European journal of preventive cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. AClinical case reports · 2025
    Article
  2. Review
  3. Review
  4. An Overview of Sport Participation and Exercise Prescription in Mitral Valve Disease.Journal of cardiovascular development and disease · 2023
    Review
  5. Genetics and pathophysiology of mitral valve prolapse.Frontiers in cardiovascular medicine · 2023
    Review
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Yasmine L HiemstraDepartment of Cardiology, Leiden University Medical Center, The Netherlands.
Aniek L van WijngaardenDepartment of Cardiology, Leiden University Medical Center, The Netherlands.
Mathilde W BosDepartment of Cardiology, Leiden University Medical Center, The Netherlands.
Martin J SchalijDepartment of Cardiology, Leiden University Medical Center, The Netherlands.
Robert Jm KlautzDepartment of Thoracic Surgery, Leiden University Medical Center, The Netherlands.
Jeroen J BaxDepartment of Cardiology, Leiden University Medical Center, The Netherlands.
Victoria DelgadoDepartment of Cardiology, Leiden University Medical Center, The Netherlands.
Daniela Qcm Barge-SchaapveldDepartment of Clinical Genetics, Leiden University Medical Center, The Netherlands.
Nina Ajmone MarsanDepartment of Cardiology, Leiden University Medical Center, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInitial studies have suggested the familial clustering of mitral valve prolapse, but most of them were either community based among unselected individuals or applied non-specific diagnostic criteria. Therefore little is known about the familial distribution of mitral regurgitation in a referral-type population with a more severe mitral valve prolapse phenotype. The objective of this study was to evaluate the presence of familial mitral regurgitation in patients undergoing surgery for mitral valve prolapse, differentiating patients with Barlow's disease, Barlow forme fruste and fibro-elastic deficiency.

methodsA total of 385 patients (62 ± 12 years, 63% men) who underwent surgery for mitral valve prolapse were contacted to assess cardiac family history systematically. Only the documented presence of mitral regurgitation was considered to define 'familial mitral regurgitation'. In the probands, the aetiology of mitral valve prolapse was defined by surgical observations.

resultsA total of 107 (28%) probands were classified as having Barlow's disease, 85 (22%) as Barlow forme fruste and 193 (50%) patients as fibro-elastic deficiency. In total, 51 patients (13%) reported a clear family history for mitral regurgitation; these patients were significantly younger, more often diagnosed with Barlow's disease and also reported more sudden death in their family as compared with 'sporadic mitral regurgitation'. In particular, 'familial mitral regurgitation' was reported in 28 patients with Barlow's disease (26%), 15 patients (8%) with fibro-elastic deficiency and eight (9%) with Barlow forme fruste (

conclusionsIn a large cohort of patients operated for mitral valve prolapse, the self-reported prevalence of familial mitral regurgitation was 26% in patients with Barlow's disease and still 8% in patients with fibro-elastic deficiency, highlighting the importance of familial anamnesis and echocardiographic screening in all mitral valve prolapse patients.

Indexed as

AgedFemaleGenetic Predisposition to DiseaseHeredityHumansMaleMiddle AgedMitral Valve InsufficiencyMitral Valve ProlapseNetherlandsPedigreePhenotypePrevalenceSeverity of Illness Indexepidemiologygeneticsmitral valve prolapseOrganic mitral regurgitation

Identifiers

PMID31475862
PMCPMC7008556

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.