ArticleAnimal genetics2019
Two linked TBXT (brachyury) gene polymorphisms are associated with the tailless phenotype in fat-rumped sheep.
Article in Animal genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Retention of embryonic positional identity signatures in the adult sheep tail: evidence from HOXB13 spatial RNA expression gradients.Scientific reports · 2026Article
- Genomic insights into the population history of fat-tailed sheep and identification of two mutations that contribute to fat tail adipogenesis.Journal of advanced research · 2026Article
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- Whole-genome resequencing of the Kazakh coarse-wool fat-tailed sheep identifies functional variants in disease-associated genes.Frontiers in veterinary science · 2026Article
- Genome edited sheep generated by zygote electroporation of prime editor ribonucleoproteins.Frontiers in genome editing · 2026Article
- Transposable Elements Regulate Tail Development and Fat Deposition in Sheep Fetuses.Animals : an open access journal from MDPI · 2025Article
- Article
- Mouflon and Domestic Sheep Phylogeny: Ancestry, Domestication, and Evolutionary Dynamics.Life (Basel, Switzerland) · 2025Review
- A combination of transcriptomics and epigenomics identifies genes and regulatory elements involved in embryonic tail development in the mouse.BMC biology · 2025Article
- Association of Sheep Tail Type with the T Gene Single Nucleotide Polymorphisms Loci.Life (Basel, Switzerland) · 2025Article
- Population structure and selective signature analysis of local sheep breeds in Xinjiang, China based on high-density SNP chip.Scientific reports · 2024Article
- Whole-genome resequencing of Chinese indigenous sheep provides insight into the genetic basis underlying climate adaptation.Genetics, selection, evolution : GSE · 2024Article
- Phenotype transition from wild mouflon to domestic sheep.Genetics, selection, evolution : GSE · 2024Review
- A Single-Cell Atlas of an Early Mongolian Sheep Embryo.Veterinary sciences · 2023Article
- Generation of sheep with defined FecBBMC genomics · 2023Article
- Design and characterization of a high-resolution multiple-SNP capture array by target sequencing for sheep.Journal of animal science · 2023Article
- Ovine HOXB13: expanding the gene repertoire of sheep tail patterning and implications in genetic improvement.Communications biology · 2022Article
- Genomic analyses of wild argali, domestic sheep, and their hybrids provide insights into chromosome evolution, phenotypic variation, and germplasm innovation.Genome research · 2022Article
- Genetics of the phenotypic evolution in sheep: a molecular look at diversity-driving genes.Genetics, selection, evolution : GSE · 2022Review
- Fine-mapping and identification of candidate causal genes for tail length in the Merinolandschaf breed.Communications biology · 2022Article
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Authors and funding
8 authors at 2 institutions in 4 countries.
Funding
Abstract
T-box transcription factor T (TBXT), encoding the brachyury protein, is an embryonic nuclear transcription factor involved in mesoderm formation and differentiation. Previous studies indicate that TBXT mutations are responsible for the tailless or short-tailed phenotype of many vertebrates. To verify whether the tailless phenotype in fat-rumped sheep is associated with TBXT mutations, exon 2 of the TBXT gene for 301 individuals belonging to 13 Chinese and Iranian sheep breeds was directly sequenced. Meanwhile, 380 samples were used to detect the genotypes of the candidate variations by mapping to their reads databases in the Sequence Read Archive repository of GenBank. The results showed that one missense mutation, c.334G>T (GGG>TGG) with a completely linked synonymous variant c.333G>C (CCG>CCC) was found to be associated with the 'tailless' characteristic in typical fat-rumped sheep breeds. The c.334G>T transversion led to the conversion of glycine to tryptophan at the 112th amino acid in the T-box domain of the brachyury protein. In addition, crossbreeding experiments for long-tailed and tailless sheep showed that CT/CT allele of nucleotides (nt) 333 and 334, a recessive mutation, would cause sheep tails to be shorter, suggesting that these two linked variants at nucleotides 333 and 334 in TBXT are probably causative mutations responsible for the tailless phenotype in sheep.
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