Evidence map›Paper›PMID 31475738›Full record

ArticleThe EMBO journal2019

Cyclin F-dependent degradation of E2F7 is critical for DNA repair and G2-phase progression.

Ruixue Yuan, Qingwu Liu, Hendrika A Segeren, Laurensia Yuniati, Daniele Guardavaccaro, Robert J Lebbink, Bart Westendorp, Alain de Bruin

Open access · hybridAbstract read
In one paragraph

Article in The EMBO journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 61 citations in OpenAlex.

  1. Review
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  4. E2F7 targets S100A2 to suppress CD8Journal of molecular medicine (Berlin, Germany) · 2026
    Article
  5. Article
  6. Review
  7. The E2F family: a ray of dawn in cardiomyopathy.Molecular and cellular biochemistry · 2025
    Review
  8. Review
  9. Article
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  11. E2F7 drives autotaxin/Enpp2 transcription via chromosome looping: Repression by p53 in murine but not in human carcinomas.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Ruixue YuanDepartment of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0001-9813-6683
Qingwu LiuDepartment of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Hendrika A SegerenDepartment of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0002-8115-6482
Laurensia YuniatiHubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands.
Daniele GuardavaccaroHubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands.
Robert J LebbinkMedical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Bart WestendorpDepartment of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0003-1043-3638
Alain de BruinDepartment of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0001-8579-2649
Utrecht University · NLUniversity Medical Center Utrecht · NLUniversity Medical Center Groningen · NLUniversity of Verona · IT

Funding

China Scholarship Council (CSC) 201306380101China Scholarship Council (CSC) 201706140153KWF Kankerbestrijding (Dutch Cancer Society) HUBR 2014-6806KWF Kankerbestrijding (Dutch Cancer Society) UU2012-5667KWF Kankerbestrijding (Dutch Cancer Society) UU2013-5777Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) ALW-IN11-28
6 · The paper itself

Abstract

E2F7 and E2F8 act as tumor suppressors via transcriptional repression of genes involved in S-phase entry and progression. Previously, we demonstrated that these atypical E2Fs are degraded by APC/C

Indexed as

DNA RepairProteolysisCell Cycle CheckpointsCyclinsDNA DamageDNA ReplicationE2F7 Transcription FactorG2 PhaseHeLa CellsHumansProtein BindingRepressor ProteinsUbiquitinationUbiquitin-Protein LigasesCCNF protein, humanCyclinsE2F7 protein, humanE2F7 Transcription FactorE2F8 protein, humanRepressor ProteinsUbiquitin-Protein Ligasescell cycleDNA damageE2FproteolysisSCF cyclin F

Identifiers

PMID31475738
PMCPMC6792010
OpenAlexW2971922700

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.