SynthesisCancer medicine2019
Revisit of an unanswered question by pooled analysis of eight cohort studies in Japan: Does cigarette smoking and alcohol drinking have interaction for the risk of esophageal cancer?
Synthesis in Cancer medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The Combined Effects of Alcohol Consumption and Smoking on Cancer Risk by Exposure Level: A Systematic Review and Meta-Analysis.Journal of Korean medical science · 2024Pooled it
- Environmental and life-style risk factors for esophageal squamous cell carcinoma in Africa: a systematic review and meta-analysis.BMC public health · 2023Pooled it
- The potential for reducing alcohol consumption to prevent esophageal cancer morbidity in Asian heavy drinkers: a systematic review and meta-analysis.Esophagus : official journal of the Japan Esophageal Society · 2022Pooled it
- Revisit of an unanswered question by pooled analysis of eight cohort studies in Japan: Does cigarette smoking and alcohol drinking have interaction for the risk of esophageal cancer?Cancer medicine · 2019Pooled it
- Alcohol consumption and upper aerodigestive tract squamous cell carcinoma: evidence from 28 prospective cohorts.Journal of the National Cancer Institute · 2025Article
- Global, regional and national burden of lip and oral cavity cancer from 1990 to 2021 and projections to 2036.BMC oral health · 2025Article
- Estimating additive interaction in 2-stage individual participant data meta-analysis.American journal of epidemiology · 2025Article
- Alcohol consumption and esophageal cancer risk: unveiling DLEU2 as a key immune modulator through Mendelian randomization and transcriptomic analysis.Discover oncology · 2025Article
- High mean corpuscular volume as a predictor of esophageal cancer: A cohort study based on the Japanese Shizuoka Kokuho Database.PloS one · 2025Article
- Alcohol dependence and consumption status are related to smoking status: A cross-sectional study of data from the Japan Society and New Tobacco Internet Survey 2023.Tobacco prevention & cessation · 2025Article
- Dietary Habits, Nutrition Intake, and Alcohol Consumption Based on Types of Smoking and Smoking Status: A Cross-Sectional Study.Nutrients · 2024Article
- Oncologists' communication about tobacco and alcohol use during treatment for esophagogastric cancer: a qualitative observational study of simulated consultations.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Observational
- Efficacy and Safety of Salvage-line Nivolumab Monotherapy for Advanced Esophageal Squamous Cell Carcinoma: Comparison of 240 mg Versus 480 mg Doses.Journal of gastrointestinal cancer · 2024Article
- CSPG4P12 polymorphism served as a susceptibility marker for esophageal cancer in Chinese population.BMC cancer · 2024Article
- Long-term prognosis after endoscopic submucosal dissection for esophageal cancer in older adult patients.BMC gastroenterology · 2024Article
- Social Outbreak in Chile, and Its Association with the Effects Biological, Psychological, Social, and Quality of Life.International journal of environmental research and public health · 2023Article
- Alcohol consumption and cancer incidence in women: interaction with smoking, body mass index and menopausal hormone therapy.BMC cancer · 2023Article
- Esophageal cancer practice guidelines 2022 edited by the Japan esophageal society: part 1.Esophagus : official journal of the Japan Esophageal Society · 2023Article
- Cigarette Smoke Enhances the Malignant Phenotype of Esophageal Adenocarcinoma Cells by Disrupting a Repressive Regulatory Interaction Between miR-145 and LOXL2.Laboratory investigation; a journal of technical methods and pathology · 2023Article
- Effects of Perioperative Oral Management in Patients with Cancer.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Cigarette smoking and alcohol drinking are two major risk factors for esophageal cancer. Not all, but several of case-control studies have indicated interaction between the two factors; however, no prospective study has validated this phenomenon to date. Therefore, the interaction between smoking and alcohol drinking is still open-ended question. To answer this, we conducted a pooled analysis using large-scale population-based cohort studies in Japan. Male subjects from eight cohort studies were included. Cigarette smoking and alcohol drinking were both categorized categorically (never/ever), and in the three consumption levels of pack years and ethanol consumption/day. Effects of smoking and drinking in each study were estimated by Cox regression models. The study-specific results were combined through meta-analysis to obtain summary effects of hazard ratios (HRs) and measures of interactions at both additive and multiplicative scales. Population attributable fractions (PAFs) from smoking and drinking were obtained using distributions of exposures and fully adjusted HRs. In 162 826 male subjects, 954 esophageal cancer incidences were identified. HRs of ever smoking, ever drinking, and their combination were 2.92 (1.59-5.36), 2.73 (1.78-4.18), and 8.86 (4.82-16.30), respectively. Interaction between cigarette smoking and alcohol drinking was significantly positive on the additive scale, but not significant on the multiplicative scale. The joint effect of smoking and drinking in three levels of evaluation showed a similar significant super-additive interaction. PAFs from smoking, drinking, and their combination were 55.4%, 61.2%, and 81.4%, respectively. Cigarette smoking and alcohol drinking had a significant positive additive interaction for esophageal cancer risk.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.