Evidence map›Paper›PMID 31475439›Full record

ArticleEMBO reports2019

CENP-C unwraps the human CENP-A nucleosome through the H2A C-terminal tail.

Ahmad Ali-Ahmad, Silvija Bilokapić, Ingmar B Schäfer, Mario Halić, Nikolina Sekulić

Open access · greenAbstract read
In one paragraph

Article in EMBO reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 73 citations in OpenAlex.

  1. Structure and function of the centromere and inner kinetochore.Nature reviews. Molecular cell biology · 2026
    Review
  2. Article
  3. Dual Roads of CENP-A for Centromere Identification.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  4. Article
  5. Determinants of centromeric nucleosome conformation.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Structure and dynamics of 2x(CENP-A/H4)Life science alliance · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. The dynamic centromere.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025
    Review
  13. Preserving centromere identity: right amounts of CENP-A at the right place and time.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025
    Review
  14. Article
  15. Solution conformational differences between conventional and CENP-A nucleosomes are accentuated by reversible deformation under high pressure.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025
    Article
  16. Article
  17. Article
  18. Cryo-EM Analysis of a Unique Subnucleosome Containing Centromere-Specific Histone Variant CENP-A.Genes to cells : devoted to molecular & cellular mechanisms · 2025
    Article
  19. Review
  20. Non-nucleosomal (CENP-A/H4)bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Ahmad Ali-AhmadCentre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo, Oslo, Norway.
Silvija BilokapićDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Ingmar B SchäferDepartment of Structural Cell Biology, Max Planck Institute of Biochemistry, Munich, Germany.
Mario HalićDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-0061-7372
Nikolina SekulićCentre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo, Oslo, Norway.ORCID 0000-0002-8027-9114
St. Jude Children's Research Hospital · USUniversity of Oslo · NOMax Planck Institute of Biochemistry · DE

Funding

Structural and functional studies of chromatin modifiersR01GM135599 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI HALIC, MARIO · 2020 to 2023
$1.5M
NIGMS NIH HHS R01 GM135599
6 · The paper itself

Abstract

Centromeres are defined epigenetically by nucleosomes containing the histone H3 variant CENP-A, upon which the constitutive centromere-associated network of proteins (CCAN) is built. CENP-C is considered to be a central organizer of the CCAN. We provide new molecular insights into the structure of human CENP-A nucleosomes, in isolation and in complex with the CENP-C central region (CENP-C

Indexed as

Amino Acid SequenceBase SequenceCentromere Protein AChromosomal Proteins, Non-HistoneDNAHistonesHumansHydrophobic and Hydrophilic InteractionsModels, MolecularNucleosomesProtein BindingProtein ConformationProtein StabilityCentromere Protein Acentromere protein CChromosomal Proteins, Non-HistoneDNAHistonesNucleosomesCENP-ACENP-Ccentromerecryo-EMnucleosome

Identifiers

PMID31475439
PMCPMC6776904
OpenAlexW2971772352

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.