ArticleDepression and anxiety2019
White matter integrity and functional predictors of response to repetitive transcranial magnetic stimulation for posttraumatic stress disorder and major depression.
Article in Depression and anxiety, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Structural-functional multilayer brain network properties and outcome of combined repetitive transcranial magnetic stimulation and psychotherapy for obsessive-compulsive disorder.NeuroImage. Clinical · 2026Trial
- White matter tracts associated with iTBS-induced heart rate deceleration and treatment response in major depressive disorder.Translational psychiatry · 2025Trial
- A review of diffusion MRI in mood disorders: mechanisms and predictors of treatment response.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Common and divergent neuroimaging features in major depression, posttraumatic stress disorder, and their comorbidity.Psychoradiology · 2024Review
- Repetitive Transcranial Magnetic Stimulation for Depression and Posttraumatic Stress Disorder in Veterans With Mild Traumatic Brain Injury.Neuromodulation : journal of the International Neuromodulation Society · 2023Article
- Electric field distribution predicts efficacy of accelerated intermittent theta burst stimulation for late-life depression.Frontiers in psychiatry · 2023Article
- Contemporary Approaches Toward Neuromodulation of Fear Extinction and Its Underlying Neural Circuits.Current topics in behavioral neurosciences · 2023Article
- Involvement of the brain-heart axis in the link between PTSD and cardiovascular disease.Depression and anxiety · 2022Review
- Revisiting Hemispheric Asymmetry in Mood Regulation: Implications for rTMS for Major Depressive Disorder.Brain sciences · 2022Review
- Sex/Gender as a Factor That Influences Transcranial Magnetic Stimulation Treatment Outcome: Three Potential Biological Explanations.Frontiers in psychiatry · 2022Article
- Treatment of major depressive disorder with bilateral theta burst stimulation: study protocol for a randomized, double-blind, placebo-controlled multicenter trial (TBS-D).European archives of psychiatry and clinical neuroscience · 2021Article
- The Effects of Repetitive Transcranial Magnetic Stimulation on Cognitive Impairment and the Brain Lipidome in a Cuprizone-Induced Mouse Model of Demyelination.Frontiers in neuroscience · 2021Article
- Correlations Among mRNA Expression Levels of ATP7A, Serum Ceruloplasmin Levels, and Neuronal Metabolism in Unmedicated Major Depressive Disorder.The international journal of neuropsychopharmacology · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundRecent evidence suggests that therapeutic repetitive transcranial magnetic stimulation (TMS) is an effective treatment for pharmacoresistant posttraumatic stress disorder (PTSD) and comorbid major depressive disorder (MDD). We recently demonstrated that response to 5 Hz TMS administered to the dorsolateral prefrontal cortex was predicted by functional connectivity of the medial prefrontal (MPFC) and subgenual anterior cingulate cortex (sgACC). This functionally-defined circuit is a novel target for treatment optimization research, however, our limited knowledge of the structural pathways that underlie this functional predisposition is a barrier to target engagement research.
methodsTo investigate underlying structural elements of our previous functional connectivity findings, we submitted pre-TMS diffusion-weighted imaging data from 20 patients with PTSD and MDD to anatomically constrained tract-based probabilistic tractography (FreeSurfer's TRActs Constrained by UnderLying Anatomy). Averaged pathway fractional anisotropy (FA) was extracted from four frontal white matter tracts: the forceps minor, cingulum, anterior thalamic radiations (ATRs), and uncinate fasciculi. Tract FA statistics were treated as explanatory variables in backward regressions testing the relationship between tract integrity and functional connectivity coefficients from MPFC and sgACC predictors of symptom improvement after TMS.
resultsFA in the ATRs was consistently associated with symptom improvement in PTSD and MDD (Bonferroni-corrected p < .05).
conclusionWe found that structural characteristics of the ATR account for significant variance in individual-level functional predictors of post-TMS improvement. TMS optimization studies should target this circuit either in stand-alone or successive TMS stimulation protocols.
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