Evidence map›Paper›PMID 31475380›Full record

ArticleThe EMBO journal2019

Nomenclature for cellular plasticity: are the terms as plastic as the cells themselves?

Jason C Mills, Ben Z Stanger, Maike Sander

Abstract read
In one paragraph

Article in The EMBO journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Cell plasticity in cancer and therapy resistance.Experimental & molecular medicine · 2026
    Review
  2. Review
  3. Article
  4. The Fronto-Temporal Cortex Has Increased Subcortical Connectivity In Utero and Plasticity in Adulthood.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  5. Article
  6. Article
  7. Live-cell omics with Raman spectroscopy.Microscopy (Oxford, England) · 2025
    Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Highlights of how single-cell analyses are illuminating differentiation and disease in the gastric corpus.American journal of physiology. Gastrointestinal and liver physiology · 2024
    Review
  15. β-Cell Heterogeneity and Plasticity.Advances in anatomy, embryology, and cell biology · 2024
    Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jason C MillsDivision of Gastroenterology, Department of Medicine, Department of Developmental Biology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-0402-4662
Ben Z StangerDepartment of Medicine, Department of Cell and Developmental Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-0410-4037
Maike SanderDepartment of Pediatrics, Department of Cellular & Molecular Medicine, Pediatric Diabetes Research Center, University of California, San Diego, San Diego, CA, USA.ORCID 0000-0001-5308-7785

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
Nkx6 gene function in pancreas developmentR01DK068471 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI WORTHAM, MATTHEW · 2004 to 2024
$6.6M
REGULATION OF ATROPHY-INDUCED PROGENITOR CELLS IN THE GASTRIC CORPUSR01DK094989 · NIDDK · WASHINGTON UNIVERSITY · PI Jason C Mills · 2012 to 2026
$6.1M
MECHANISMS OF CHIEF CELL DEDIFFERENTIATIONR01DK105129 · NIDDK · WASHINGTON UNIVERSITY · PI Jason C Mills · 2015 to 2026
$5.4M
Novel insights into nutrient-dependent regulation of beta cell proliferationR01DK078803 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDER, MAIKE · 2007 to 2022
$4.4M
Mechanisms of bile duct reprogrammingR01DK083355 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI GROMPE, MARKUS, STANGER, BEN Z · 2009 to 2020
$4.3M
The Role of EBI3 in Regulating Gastritis and Gastric CarcinogenesisR01DK110406 · NIDDK · SAINT LOUIS UNIVERSITY · PI DIPAOLO, RICHARD J · 2016 to 2020
$2.3M
Mechanisms Governing Expansion of Embryonic Progenitor Cells (EPCs) inMetaplasiaR01CA239645 · NCI · WASHINGTON UNIVERSITY · PI MILLS, JASON C · 2020 to 2024
$2.1M
The Role of Inflammation in Regulating Gastritis and Gastric CarcinogenesisR56DK110406 · NIDDK · SAINT LOUIS UNIVERSITY · PI DIPAOLO, RICHARD J · 2021 to 2021
$486k
Alvin J. Siteman Cancer Center/Barnes Jewish Hospital Foundation Cancer Frontier FundHHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK068471HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK078803HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK094989HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK105129HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK110406NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA239645NIDDK NIH HHS R01 DK068471NIDDK NIH HHS R01 DK078803NIDDK NIH HHS R01 DK083355NIDDK NIH HHS R01 DK094989NIDDK NIH HHS R01 DK105129NIDDK NIH HHS R01 DK110406NIDDK NIH HHS R56 DK110406NIH National Cancer Institute P30CA091842
6 · The paper itself

Abstract

It is now recognized that cell identity is more fluid, and tissues more plastic, than previously thought. The plasticity of cells is relevant to diverse fields, most notably developmental and stem cell biology, regenerative medicine, and cancer biology. To date, a comprehensive and uniform nomenclature to define distinct cell states and their injury-induced interconversions has been elusive. The first Keystone Symposium devoted exclusively to cellular plasticity in regeneration and tumorigenesis was held on January 2019 in Keystone, Colorado, and featured a workshop on terminology in the cell plasticity field. Definitions for terms such as plasticity, de- and transdifferentiation, reversion, and paligenosis were discussed. Here, we summarize the content and tenor of the symposium and nomenclature-focused workshop with regard to terms in the field. We outline the challenges with current definitions and recommend best practices and approaches to developing an accurate and acceptable nomenclature in the future.

Indexed as

Cell PlasticityTerminology as TopicAnimalsCarcinogenesisCongresses as TopicHumansPlasticsRegenerative MedicinePlastics

Identifiers

PMID31475380
PMCPMC6769377

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.