Evidence map›Paper›PMID 31475305›Full record

ReviewClinical autonomic research : official journal of the Clinical Autonomic Research Society2020

Human papillomavirus (HPV) vaccine and autonomic disorders: a position statement from the American Autonomic Society.

Alexandru Barboi, Christopher H Gibbons, Felicia Axelrod, Eduardo E Benarroch, Italo Biaggioni, Mark W Chapleau, Gisela Chelimsky, Thomas Chelimsky, William P Cheshire, Victoria E Claydon and 13 more

Abstract readReviewConsensus Statement
PubMed Publisher
In one paragraph

Review in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Response to: Human papillomavirus (HPV) vaccine safety concerning POTS, CRPS and related conditions.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020
    Article
  13. Human papillomavirus (HPV) vaccine safety concerning POTS, CRPS and related conditions.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Alexandru BarboiDepartment of Neurology, NorthShore University Health System, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA. ABarboi@northshore.org.
Christopher H GibbonsDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA, USA.
Felicia AxelrodDepartments of Neurology, New York University, New York, NY, USA.
Eduardo E BenarrochDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Italo BiaggioniDivision of Clinical Pharmacology, Department of Medicine, Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Mark W ChapleauDepartments of Medicine and Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA.
Gisela ChelimskyDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.
Thomas ChelimskyDepartment of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA.
William P CheshireDepartment of Neurology, Mayo Clinic, Jacksonville, FL, USA.
Victoria E ClaydonDepartment of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada.
Roy FreemanDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA, USA.
David S GoldsteinAutonomic Medicine Section, National Institute of Neurological, Diseases and Stroke, National Institutes of Health, Bethesda, MD, USA.
Michael J JoynerDepartment of Anesthesia and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
Horacio KaufmannDepartments of Neurology, New York University, New York, NY, USA.
Phillip A LowDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Lucy Norcliffe-KaufmannDepartments of Physiology and Neurosciences, New York University, New York, NY, USA.
David RobertsonDivision of Clinical Pharmacology, Department of Medicine, Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Cyndya A ShibaoDivision of Clinical Pharmacology, Department of Medicine, Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Wolfgang SingerDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Howard SnapperCardiology Division, Wellstar Healthcare System, Atlanta, GA, USA.
Steven VerninoDepartment of Neurology and Neurotherapeutics, UT Southwestern Medical Center, Dallas, TX, USA.
Satish R RajDivision of Clinical Pharmacology, Department of Medicine, Autonomic Dysfunction Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
American Autonomic Society

Funding

Mechanisms of Parkinson Disease and Related DisordersZIANS003033 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI GOLDSTEIN, DAVID · 2009 to 2022
$8.2M
Neurophysiologic & Autonomic Characterization of Interstitial Cystitis/Painful BlR01DK083538 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI HELMS, ANN K · 2009 to 2020
$6.6M
NIDDK NIH HHS R01 DK083538
6 · The paper itself

Abstract

introductionHuman papillomavirus (HPV) vaccination has been anecdotally connected to the development of dysautonomia, chronic fatigue, complex regional pain syndrome and postural tachycardia syndrome.

objectivesTo critically evaluate a potential connection between HPV vaccination and the above-noted conditions.

methodsWe reviewed the literature containing the biology of the virus, pathophysiology of infection, epidemiology of associated cancers, indications of HPV vaccination, safety surveillance data and published reports linking HPV vaccination to autonomic disorders.

resultsAt this time, the American Autonomic Society finds that there are no data to support a causal relationship between HPV vaccination and CRPS, chronic fatigue, and postural tachycardia syndrome to other forms of dysautonomia.

conclusionCertain conditions are prevalent in the same populations that are vaccinated with the HPV vaccine (peri-pubertal males and females). This association, however, is an insufficient proof of causality.

Indexed as

Autonomic Nervous System DiseasesFatigue Syndrome, ChronicHumansPapillomavirus InfectionsPapillomavirus VaccinesPostural Orthostatic Tachycardia SyndromePrimary DysautonomiasSocieties, MedicalUnited StatesPapillomavirus VaccinesAutonomic dysfunctionConsensus statementHPVPostural tachycardia syndromeVaccine

Identifiers

PMID31475305

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.