ArticleAnnals of translational medicine2019
Uric acid level changes after bariatric surgery in obese subjects with type 2 diabetes mellitus.
Article in Annals of translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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10 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Effects of Metabolic and Bariatric Surgery on Serum Uric Acid and its Association with Renal Function, and Visceral Adiposity: A Systematic Review and Meta-Analysis.Obesity surgery · 2026Pooled it
- Insights into renal damage in hyperuricemia: Focus on renal protection (Review).Molecular medicine reports · 2025Review
- Impact of Sleeve Gastrectomy on Uric Acid Levels in Patients with Obesity: A Comparative Study.Obesity surgery · 2024Article
- Changes in Serum Urate Levels after Bariatric Surgery in Patients with Obesity: An Observational Study.Obesity surgery · 2024Observational
- Review
- The Impact of Obesity Surgery on Serum Uric Acid in People With Severe Obesity: A Retrospective Study.Clinical nutrition research · 2023Article
- The serum uric acid is longitudinally related to patients global assessment of disease activity in male patients with axial spondyloarthritis.BMC musculoskeletal disorders · 2022Article
- Prevalence and Clinical Predictors of Hyperuricemia in Chinese Bariatric Surgery Patients.Obesity surgery · 2022Article
- Metabolic surgery in China: present and future.Journal of molecular cell biology · 2021Article
- A Longitudinal Study of the Antioxidant Barrier and Oxidative Stress in Morbidly Obese Patients after Bariatric Surgery. Does the Metabolic Syndrome Affect the Redox Homeostasis of Obese People?Journal of clinical medicine · 2020Article
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5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of the study was to investigate the incidence of hyperuricemia (HU) in obese subjects with type 2 diabetes mellitus (T2DM) before and after Roux-en-Y gastric bypass (RYGB), to describe the impact of this therapy in reducing uric acid levels, and its possible mechanism. This study was performed by cooperation with the First affiliated hospital of Soochow University and the Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, department of general surgery.
methodsA retrospective study was performed. From February 2015 to December 2017, we evaluated 147 obese patients with T2DM. Blood samples and other clinical data were drawn before and postoperative (1, 3, 6, 12 months after RYGB). All obese patients with T2DM underwent laparoscopic Roux-en-Y gastric bypass surgery (LRYGB). Different gender with HU were compared before and after surgery.
resultsA total of 147 patients received LRYGB (75 were female, 72 were male), and 48 patients with HU (22 were female, 26 were male). Four women and 2 men were lost to follow-up, they were excepted from this study. No patients with HU lost to follow-up. There's an intuitive downward trend about uric acid levels both in men and women, with men from 497.9 µmol/L before surgery to 371.5 µmol/L 1 year after surgery, P=0.000; women from 432.3 to 354.1 µmol/L, P=0.002. The proportion of HU changed with men from 37.1% (26/70) before surgery to 12.9% (9/70) one year after surgery, women from 31.0% (22/71) to 14.1% (10/71). The results of binary logistic regression analysis confirmed that triglycerides were clinical predictors for HU remission (P=0.004). No major late surgical complications were reported.
conclusionsOur data showed that, bariatric surgery was effective to decrease the levels of serum uric acid (SUA) in obese patients with T2DM. Compared with traditional drug treatment, this shows a possible treatment of HU by RYGB. The remission of HU was associated with the decreased triglyceride levels in obese patients with T2DM, independent of BMI. The potential role of triglycerides in the remission of HU merits further study.
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