Evidence map›Paper›PMID 31475177›Full record

ArticleAnnals of translational medicine2019

Deep convolutional neural network Inception-v3 model for differential diagnosing of lymph node in cytological images: a pilot study.

Qing Guan, Xiaochun Wan, Hongtao Lu, Bo Ping, Duanshu Li, Li Wang, Yongxue Zhu, Yunjun Wang, Jun Xiang

Open access · diamondAbstract read
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Article in Annals of translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.

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  16. Research on the classification of lymphoma pathological images based on deep residual neural network.Technology and health care : official journal of the European Society for Engineering and Medicine · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Qing GuanDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Xiaochun WanDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Hongtao LuDepertment of Computer Science and Engineering, Shanghai Jiaotong University, Shanghai 200240, China.
Bo PingDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Duanshu LiDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Li WangDepertment of Computer Science and Engineering, Shanghai Jiaotong University, Shanghai 200240, China.
Yongxue ZhuDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Yunjun WangDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Jun XiangDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Fudan University Shanghai Cancer Center · CNShanghai Medical College of Fudan University · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn this study, we exploited the Inception-v3 deep convolutional neural network (DCNN) model to differentiate cervical lymphadenopathy using cytological images.

methodsA dataset of 80 cases was collected through the fine-needle aspiration (FNA) of enlarged cervical lymph nodes, which consisted of 20 cases of reactive lymphoid hyperplasia, 24 cases of non-Hodgkin's lymphoma (NHL), 16 cases of squamous cell carcinoma (SCC), and 20 cases of adenocarcinoma. The images were cropped into fragmented images and divided into a training dataset and a test dataset. Inception-v3 was trained to make differential diagnoses and then tested. The features of misdiagnosed images were further analysed to discover the features that may influence the diagnostic efficiency of such a DCNN.

resultsA total of 742 original images were derived from the cases, from which a total of 7,934 fragmented images were cropped. The classification accuracies for the original images of reactive lymphoid hyperplasia, NHL, SCC and adenocarcinoma were 88.46%, 80.77%, 89.29% and 100%, respectively. The total accuracy on the test dataset was 89.62%. Three fragmented images of reactive lymphoid hyperplasia and three fragmented images of SCC were misclassified as NHL. Three fragmented images of NHL were misclassified as reactive lymphoid hyperplasia, one was misclassified as SCC, and one was misclassified as adenocarcinoma.

conclusionsIn summary, after training with a large dataset, the Inception-v3 DCNN model showed great potential in facilitating the diagnosis of cervical lymphadenopathy using cytological images. Analysis of the misdiagnosed cases revealed that NHL was the most challenging cytology type for DCNN to differentiate.

Indexed as

cervical lymphadenopathycytological imagesDeep convolutional neural network (DCNN)fine-needle aspiration (FNA)Inception v3liquid-based cytology

Identifiers

PMID31475177
PMCPMC6694266
OpenAlexW2949824473

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.