Evidence map›Paper›PMID 31475168›Full record

ArticleAnnals of translational medicine2019

Alterations of irisin, adropin, preptin and BDNF concentrations in coronary heart disease patients comorbid with depression.

Wenxiu Han, Chunxiang Zhang, Hui Wang, Mengqi Yang, Yujin Guo, Gongying Li, Hailiang Zhang, Changshui Wang, Dan Chen, Chunmei Geng and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Biosensors, Recent Advances in Determination of BDNF and NfL.Cellular and molecular neurobiology · 2023
    Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Wenxiu HanInstitute of Clinical Pharmacy & Pharmacology, Jining First People's Hospital, Jining Medical University, Jining 272011, China.
Chunxiang ZhangDepartment of Cardiology, Jining First People's Hospital, Jining Medical University, Jining 272011, China.
Hui WangDepartment of Gynecology, Jinxiang People's Hospital, Jining 272200, China.
Mengqi YangInstitute of Clinical Pharmacy & Pharmacology, Jining First People's Hospital, Jining Medical University, Jining 272011, China.
Yujin GuoInstitute of Clinical Pharmacy & Pharmacology, Jining First People's Hospital, Jining Medical University, Jining 272011, China.
Gongying LiDepartment of Mental Health, Jining Medical University, Jining 272000, China.
Hailiang ZhangInstitute of Clinical Pharmacy & Pharmacology, Jining First People's Hospital, Jining Medical University, Jining 272011, China.
Changshui WangInstitute of Clinical Pharmacy & Pharmacology, Jining First People's Hospital, Jining Medical University, Jining 272011, China.
Dan ChenInstitute of Clinical Pharmacy & Pharmacology, Jining First People's Hospital, Jining Medical University, Jining 272011, China.
Chunmei GengInstitute of Clinical Pharmacy & Pharmacology, Jining First People's Hospital, Jining Medical University, Jining 272011, China.
Pei JiangInstitute of Clinical Pharmacy & Pharmacology, Jining First People's Hospital, Jining Medical University, Jining 272011, China.
Jining Medical University · CNJining First People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDepression is a well-known co-morbidity of coronary heart disease (CHD) and these two diseases share common risk mechanisms. Here, the aim of this study was to investigate the possible link between energy homeostasis regulation and CHD patients comorbid with depression.

methodsTwo hundred and nine CHD patients and 101 matched healthy individuals were included. Demographic, clinical data were collected, serum irisin, adropin, preptin and brain-derived neurotrophic factor (BDNF) levels were determined by a double-antibody sandwich enzyme-linked immunosorbent assay (DAS-ELISA), and the depression was scored by Patient Health Questionnaire-9 (PHQ-9). Correlation analysis as well as multiple linear regression was used to assess the relationship between the three peptides, BDNF serum levels and PHQ-9 scores.

resultsIrisin serum level was significantly lower in CHD patients without depression as compared with healthy controls (P=0.002), as well as adropin (P=0.000), preptin (P=0.000) and BDNF (P=0.000). Furthermore, similar trends were observed in CHD patients with depression in terms of irisin, adropin and BDNF as compared with CHD patients without depression (P=0.006; P=0.003; P=0.002; respectively). Multiple logistic regression results confirmed the contribution of irisin and BDNF to the occurrence of depression in CHD. Interestingly, correlations analysis revealed significant negative correlations between PHQ-9 scores and irisin, adropin, BDNF level (r=-0.43, P<0.01; r=-0.29, P<0.05; r=-0.45, P<0.001 respectively), and irisin serum level was positively correlated with BDNF (r=0.38, P<0.01).

conclusionsOur study firstly identified the role of energy homeostasis in the susceptibility to depression in CHD patients, and the interaction between irisin and BDNF could trigger the imbalance of energy homeostasis that occurs in depression of CHD patients.

Indexed as

adropincoronary heart disease (CHD)depressionIrisinpreptin

Identifiers

PMID31475168
PMCPMC6694242
OpenAlexW2952339019

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.