Evidence map›Paper›PMID 31475113›Full record

ArticleFrontiers in oncology2019

CXCR4-Directed Imaging in Solid Tumors.

Rudolf A Werner, Stefan Kircher, Takahiro Higuchi, Malte Kircher, Andreas Schirbel, Hans-Jürgen Wester, Andreas K Buck, Martin G Pomper, Steven P Rowe, Constantin Lapa

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 76 citations in OpenAlex.

  1. Comparison of [Molecular imaging and biology · 2024
    Trial
  2. Exploration of Chemokine Receptor 4 Targeted [Molecular imaging and biology · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. The molecular blueprint of targeted radionuclide therapy.Nature reviews. Clinical oncology · 2025
    Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Chemokine Receptor-4 Targeted PET/CT Imaging withDiagnostics (Basel, Switzerland) · 2024
    Article
  13. Review
  14. CXCR4-directed PET/CT with [European journal of nuclear medicine and molecular imaging · 2024
    Article
  15. Article
  16. Diagnostics (Basel, Switzerland) · 2024
    Article
  17. Article
  18. Advances in PET Imaging of the CXCR4 Receptor: [Seminars in nuclear medicine · 2024
    Review
  19. Review
  20. Advances in PET/CT Imaging for Breast Cancer.Journal of clinical medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Rudolf A WernerDepartment of Nuclear Medicine, University of Wuerzburg, Wuerzburg, Germany.
Stefan KircherInstitute for Pathology, University of Wuerzburg, Wuerzburg, Germany.
Takahiro HiguchiDepartment of Nuclear Medicine, University of Wuerzburg, Wuerzburg, Germany.
Malte KircherDepartment of Nuclear Medicine, University of Wuerzburg, Wuerzburg, Germany.
Andreas SchirbelDepartment of Nuclear Medicine, University of Wuerzburg, Wuerzburg, Germany.
Hans-Jürgen WesterPharmaceutical Radiochemistry, Technische Universität München, Munich, Germany.
Andreas K BuckDepartment of Nuclear Medicine, University of Wuerzburg, Wuerzburg, Germany.
Martin G PomperDivision of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Steven P RoweDivision of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Constantin LapaDepartment of Nuclear Medicine, University of Wuerzburg, Wuerzburg, Germany.
Comprehensive Cancer Center Mainfranken · DEJohns Hopkins Medicine · USUniversity of Würzburg · DEOkayama University · JPTechnical University of Munich · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite histological evidence in various solid tumor entities, available experience with CXCR4-directed diagnostics and endoradiotherapy mainly focuses on hematologic diseases. With the goal of expanding the application of CXCR4 theranostics to solid tumors, we aimed to elucidate the feasibility of CXCR4-targeted imaging in a variety of such neoplasms.

Indexed as

[68Ga]Pentixaforchemokine receptorCXCR4solid tumorstheranostics

Identifiers

PMID31475113
PMCPMC6702266
OpenAlexW2966400779

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.