Evidence map›Paper›PMID 31475011›Full record

ArticleFrontiers in immunology2019

The DNA Methylation Inhibitor Zebularine Controls CD4

Yanli Zou, Xiao Hu, Lauren P Schewitz-Bowers, Madeleine Stimpson, Li Miao, Xiaofei Ge, Liu Yang, Yan Li, Paul W Bible, Xiaofeng Wen and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

  1. New perspectives on DNA methylation modifications in ocular diseases.International journal of ophthalmology · 2025
    Review
  2. Review
  3. Review
  4. Article
  5. CD4International journal of molecular sciences · 2021
    Review
  6. Regulatory T Cells-Related Genes Are under DNA Methylation Influence.International journal of molecular sciences · 2021
    Review
  7. Epigenetic Modifications and Therapy in Uveitis.Frontiers in cell and developmental biology · 2021
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Yanli ZouState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Xiao HuState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Lauren P Schewitz-BowersTranslational Health Sciences, University of Bristol, Bristol, United Kingdom.
Madeleine StimpsonTranslational Health Sciences, University of Bristol, Bristol, United Kingdom.
Li MiaoState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Xiaofei GeState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Liu YangState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Yan LiState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Paul W BibleState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Xiaofeng WenState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Jing Jing LiState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Yizhi LiuState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Richard W J LeeTranslational Health Sciences, University of Bristol, Bristol, United Kingdom.
Lai WeiState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Sun Yat-sen University · CNMoorfields Eye Hospital NHS Foundation Trust · GBNational Institute for Health Research · GBUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CD4

Indexed as

AnimalsAutoimmune DiseasesCD4-Positive T-LymphocytesCells, CulturedCytidineDNA MethylationFemaleForkhead Transcription FactorsHumansInflammationInterferon-gammaInterleukin-17MiceMice, Inbred C57BLPrincipal Component AnalysisUveitisCytidineForkhead Transcription FactorsFoxp3 protein, mouseIFNG protein, mouseIl17a protein, mouseInterferon-gammaInterleukin-17pyrimidin-2-one beta-ribofuranosideCD4+ T cellDNA methylation inhibitorintraocular inflammationuveitiszebularine

Identifiers

PMID31475011
PMCPMC6706956
OpenAlexW2966125339

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.