Evidence map›Paper›PMID 31475004›Full record

ArticleFrontiers in immunology2019

A Tridimensional Model for NK Cell-Mediated ADCC of Follicular Lymphoma.

Emilie Decaup, Cédric Rossi, Pauline Gravelle, Camille Laurent, Julie Bordenave, Marie Tosolini, Anne Tourette, Emeline Perrial, Charles Dumontet, Mary Poupot and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Article
  3. Goodbye flat lymphoma biology.FEBS letters · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Frontiers in immunology · 2023
    Review
  11. Review
  12. Three-dimensional models: a novel approach for lymphoma research.Journal of cancer research and clinical oncology · 2022
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 2 countries.

Emilie DecaupCentre de Recherches en Cancérologie de Toulouse (CRCT), UMR1037 INSERM, Université Toulouse III: Paul-Sabatier, ERL5294 CNRS, Université de Toulouse, Toulouse, France.
Cédric RossiCentre de Recherches en Cancérologie de Toulouse (CRCT), UMR1037 INSERM, Université Toulouse III: Paul-Sabatier, ERL5294 CNRS, Université de Toulouse, Toulouse, France.
Pauline GravelleCentre de Recherches en Cancérologie de Toulouse (CRCT), UMR1037 INSERM, Université Toulouse III: Paul-Sabatier, ERL5294 CNRS, Université de Toulouse, Toulouse, France.
Camille LaurentCentre de Recherches en Cancérologie de Toulouse (CRCT), UMR1037 INSERM, Université Toulouse III: Paul-Sabatier, ERL5294 CNRS, Université de Toulouse, Toulouse, France.
Julie BordenaveCentre de Recherches en Cancérologie de Toulouse (CRCT), UMR1037 INSERM, Université Toulouse III: Paul-Sabatier, ERL5294 CNRS, Université de Toulouse, Toulouse, France.
Marie TosoliniPôle Technologique du Centre de Recherches en Cancérologie de Toulouse, Toulouse, France.
Anne TouretteINSERM1052/CNRS5286/Université Claude Bernard, Lyon, France.
Emeline PerrialINSERM1052/CNRS5286/Université Claude Bernard, Lyon, France.
Charles DumontetINSERM1052/CNRS5286/Université Claude Bernard, Lyon, France.
Mary PoupotCentre de Recherches en Cancérologie de Toulouse (CRCT), UMR1037 INSERM, Université Toulouse III: Paul-Sabatier, ERL5294 CNRS, Université de Toulouse, Toulouse, France.
Christian KleinRoche Pharmaceutical Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland.
Ariel SavinaInstitut Roche, Boulogne-Billancourt, France.
Jean-Jacques FourniéCentre de Recherches en Cancérologie de Toulouse (CRCT), UMR1037 INSERM, Université Toulouse III: Paul-Sabatier, ERL5294 CNRS, Université de Toulouse, Toulouse, France.
Christine BezombesCentre de Recherches en Cancérologie de Toulouse (CRCT), UMR1037 INSERM, Université Toulouse III: Paul-Sabatier, ERL5294 CNRS, Université de Toulouse, Toulouse, France.
Centre National de la Recherche Scientifique · FRCentre de Recherche en Cancérologie de Toulouse · FRInserm · FRUniversité Fédérale de Toulouse Midi-Pyrénées · FRCentre Hospitalier Universitaire de Toulouse · FRRoche (France) · FRRoche (Switzerland) · CHUniversité Toulouse III - Paul Sabatier · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Follicular lymphoma (FL) is the second most frequent subtype of B non-Hodgkin's lymphomas (NHL) for which the treatment is based on the use of anti-CD20 mAbs. NK cells play a crucial role in their mechanism of action and the number of these cells mediating antibody-dependent cell cycotoxicity (ADCC) in the peripheral blood of FL patients predict the outcome. However, their presence in FL biopsies, their activation and their role have been poorly investigated. Moreover,

Indexed as

AnimalsAntibodies, Monoclonal, HumanizedAntibody-Dependent Cell CytotoxicityAntigens, CD20Antineoplastic Agents, ImmunologicalCell Culture TechniquesCell Line, TumorCoculture TechniquesGene Expression ProfilingGene Expression Regulation, NeoplasticHumansKiller Cells, NaturalLymphoma, FollicularMice, SCIDRituximabTrastuzumabAntibodies, Monoclonal, HumanizedAntigens, CD20Antineoplastic Agents, ImmunologicalobinutuzumabRituximabTrastuzumab3D co-culture modelADCC—antibody dependent cellular cytotoxicityfollicular lymphomamodelizationNK cells

Identifiers

PMID31475004
PMCPMC6702952
OpenAlexW2966280553

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.