Evidence map›Paper›PMID 31474986›Full record

ArticleFrontiers in immunology2019

Autoimmune-Mediated Retinopathy in CXCR5-Deficient Mice as the Result of Age-Related Macular Degeneration Associated Proteins Accumulation.

Anton Lennikov, Madhu Sudhana Saddala, Anthony Mukwaya, Shibo Tang, Hu Huang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Different Therapeutic Approaches for Dry and Wet AMD.International journal of molecular sciences · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Deficiency of C-X-C chemokine receptor type 5 (CXCR5) gene causes dysfunction of retinal pigment epithelium cells.Laboratory investigation; a journal of technical methods and pathology · 2021
    Article
  9. Article
  10. Article
  11. Article
  12. Experimental Models in Neovascular Age Related Macular Degeneration.International journal of molecular sciences · 2020
    Review
  13. Transcriptome-Wide Analysis ofBiomedicines · 2020
    Article
  14. Review
  15. Targeting Lipid Metabolism for the Treatment of Age-Related Macular Degeneration: Insights from Preclinical Mouse Models.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 3 countries.

Anton LennikovDepartment of Ophthalmology, University of Missouri, Columbia, MO, United States.
Madhu Sudhana SaddalaDepartment of Ophthalmology, University of Missouri, Columbia, MO, United States.
Anthony MukwayaDepartment of Ophthalmology, Faculty of Health Sciences, Institute for Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
Shibo TangAier School of Ophthalmology, Aier Eye Institute, Central South University, Changsha, China.
Hu HuangDepartment of Ophthalmology, University of Missouri, Columbia, MO, United States.
Central South University · CNJohns Hopkins Medicine · USJohns Hopkins University · USLinköping University · SEUniversity of Missouri · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous research has shown that CXCR5

Indexed as

Disease Models, Animalalpha-Crystallin B ChainAmyloid beta-PeptidesAnimalsAutoimmunityCalcium-Binding ProteinsCell LineCyclooxygenase 2Fluorescent Antibody TechniqueMacular DegenerationMice, Inbred C57BLMice, KnockoutMicrofilament ProteinsMicrogliaMicroscopy, Electron, TransmissionReceptors, CXCR5Aif1 protein, mousealpha-Crystallin B ChainAmyloid beta-PeptidesCalcium-Binding ProteinsCryab protein, mouseCXCR5 protein, mouseCyclooxygenase 2Microfilament ProteinsPtgs2 protein, mouseReceptors, CXCR5Tjp1 protein, mouseVascular Endothelial Growth Factor AZonula Occludens-1 Proteinage macular degenerationAMDamyloid betaautoantibodyCRYAACRYABCXCL13CXCR5

Identifiers

PMID31474986
PMCPMC6702970
OpenAlexW2966756332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.