ArticleFrontiers in immunology2019
Activation of the NLRP3 Inflammasome Pathway by Prokineticin 2 in Testicular Macrophages of Uropathogenic
Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- The Liver-Testis Axis: Molecular Mechanisms and Clinical Implications.International journal of molecular sciences · 2026Review
- Advances in immunological research on male infertility.Frontiers in reproductive health · 2026Review
- Insulin‑like growth factor 2 in spermatogenesis dysfunction (Review).Molecular medicine reports · 2025Review
- Aberrant highly prokineticin 2 and its association with inflammatory indexes and functional recovery in acute ischemic stroke patients.Frontiers in neurology · 2025Article
- The Role of Cells and Cytokines in Male Infertility Induced by Orchitis.The world journal of men's health · 2024Review
- Bezafibrate alleviates diabetes-induced spermatogenesis dysfunction by inhibiting inflammation and oxidative stress.Heliyon · 2024Article
- Gasdermin D in macrophages drives orchitis by regulating inflammation and antigen presentation processes.EMBO molecular medicine · 2024Article
- Role of Endoplasmic Reticulum Stress in The Male Reproductive System.Cell journal · 2023Review
- Transcription factorZoological research · 2023Article
- Microbiology and immune mechanisms associated with male infertility.Frontiers in immunology · 2023Review
- Non-Peptide Agonists and Antagonists of the Prokineticin Receptors.Current issues in molecular biology · 2022Review
- Diet-induced obesity impairs spermatogenesis: the critical role of NLRP3 in Sertoli cells.Inflammation and regeneration · 2022Article
- Prokineticin-Receptor Network: Mechanisms of Regulation.Life (Basel, Switzerland) · 2022Review
- Identification of crucial genes mediating abdominal aortic aneurysm pathogenesis based on gene expression profiling of perivascular adipose tissue by WGCNA.Annals of translational medicine · 2021Article
- Varicocele-Mediated Male Infertility: From the Perspective of Testicular Immunity and Inflammation.Frontiers in immunology · 2021Review
- Obesity Causes Abrupt Changes in the Testicular Microbiota and Sperm Motility of Zebrafish.Frontiers in immunology · 2021Article
- Severe Acute Respiratory Syndrome Coronavirus 2 and Male Reproduction: Relationship, Explanations, and Clinical Remedies.Frontiers in physiology · 2021Review
- S100A9 Activates the Immunosuppressive Switch Through the PI3K/Akt Pathway to Maintain the Immune Suppression Function of Testicular Macrophages.Frontiers in immunology · 2021Article
- Prokineticin 2Frontiers in immunology · 2020Article
- Testicular exosomes disturb the immunosuppressive phenotype of testicular macrophages mediated by miR-155-5p in uropathogenicAsian journal of andrologyArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infections of the reproductive tract are known to contribute to testicular inflammatory impairment, leading to an increase of pro-inflammatory cytokines such as IL-1β, and a decline in sperm quality. Prokineticin 2 (PK2), a secretory protein, is closely associated with the secretion of pro-inflammatory cytokines in inflamed tissue. It was reported that increased PK2 is related to the upregulation of IL-1β, but the underlying mechanism remains elusive. Here, we illustrated that PK2 was upregulated in testicular macrophages (TM) in a rat model of uropathogenic
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