Evidence map›Paper›PMID 31474871›Full record

ArticleFrontiers in physiology2019

Lack of Renal Tubular Glucocorticoid Receptor Decreases the Thiazide-Sensitive Na

Jérémie Canonica, Simona Frateschi, Emilie Boscardin, Anna Ebering, Chloé Sergi, Yannick Jäger, Thibaud Peyrollaz, Anne-Marie Mérillat, Marc Maillard, Petra Klusonova and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. How Does Dietary Potassium Influence BP?Journal of the American Society of Nephrology : JASN · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Jérémie CanonicaDepartment of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.
Simona FrateschiDepartment of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.
Emilie BoscardinDepartment of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.
Anna EberingDepartment of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.
Chloé SergiDepartment of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.
Yannick JägerDepartment of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.
Thibaud PeyrollazDepartment of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.
Anne-Marie MérillatDepartment of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.
Marc MaillardDepartment of Nephrology Service, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.
Petra KlusonovaDepartment of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Alex OdermattNational Centre of Competence in Research "Kidney.CH", Lausanne, Switzerland.
Robert KoestersHôpital Tenon, Université Pierre et Marie Curie, Paris, France.
Anne DebonnevilleDepartment of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.
Olivier StaubDepartment of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.
Sophia N VeroutiDepartment of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.
Edith HummlerDepartment of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.
University of Lausanne · CHUniversity Hospital of Lausanne · CHUniversity of Basel · CHSorbonne Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic glucocorticoid infusion impairs NCC activity and induces a non-dipping profile in mice, suggesting that glucocorticoids are essential for daily blood pressure variations. In this paper, we studied mice lacking the renal tubular glucocorticoid receptor (GR) in adulthood (GR knockouts,

Indexed as

blood pressureblood pressure dippingglucocorticoid receptorNa+-K+-Cl– cotransportersodium and hydrogen exchanger 3sodium transportthiazide-sensitive Na+/Cl– cotransporter

Identifiers

PMID31474871
PMCPMC6702950
OpenAlexW2964045832

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.