Evidence map›Paper›PMID 31474870›Full record

ArticleFrontiers in physiology2019

The Effects of Different Signaling Pathways in Adenylyl Cyclase Stimulation on Red Blood Cells Deformability.

Alexey N Semenov, Evgeny A Shirshin, Alexei V Muravyov, Alexander V Priezzhev

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 25 citations in OpenAlex.

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  9. Diagnosis and clinical management of enzymopathies.Hematology. American Society of Hematology. Education Program · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Alexey N SemenovDepartment of Physics, Moscow State University, Moscow, Russia.
Evgeny A ShirshinDepartment of Physics, Moscow State University, Moscow, Russia.
Alexei V MuravyovDepartment of Medicine and Biology, Yaroslavl State Pedagogical University, Yaroslavl, Russia.
Alexander V PriezzhevDepartment of Physics, Moscow State University, Moscow, Russia.
Lomonosov Moscow State University · RUInternational University in Moscow · RUYaroslavl State Pedagogical University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Signaling pathways of red blood cells' (RBCs) micromechanics regulation, which are responsible for maintaining microcirculation, constitute an important property of RBC physiology. Selective control over these processes may serve as an indispensable tool for correction of hemorheological disorders, which accompany a number of systemic diseases (diabetes mellitus I&II, arterial hypertension, malaria, etc.). Activation of certain pathways involving adenylyl cyclase may provide fast adaptive regulation of RBC deformability (RBC-D). However the specific molecular conditions of intracellular signal transduction in mediating RBC microrheological properties at adenylyl cyclase stimulation remain unclear. In this paper, we present the results of the

Indexed as

adenylyl cyclaselaser ektacytometrymicrorheologyRBCs deformabilitysignaling pathways

Identifiers

PMID31474870
PMCPMC6702543
OpenAlexW2959794987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.