ReviewFrontiers in pharmacology2019
Neuropsychiatric Disorders in Chronic Kidney Disease.
Review in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.
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Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Albiflorin on Neuropsychiatric and Neurodegenerative Disorders: A Systematic Review.CNS neuroscience & therapeutics · 2025Pooled it
- Shared genetic effect of kidney function on bipolar and major depressive disorders: a large-scale genome-wide cross-trait analysis.Human genomics · 2024Pooled it
- Bringing the museum into the hospital to promote cultural wellness in patients undergoing haemodialysis through a virtual reality tour.Scientific reports · 2025Trial
- Cognitive impairment and depressive symptoms to predict renal outcome and mortality in older adult patients.PloS one · 2026Article
- Factors Influencing eHealth Literacy in Maintenance Hemodialysis and Its Relationship with Emotional Status and Quality of Life.Patient preference and adherence · 2026Article
- International variations in chronic kidney disease patients' pain experience and its management.Clinical kidney journal · 2026Article
- Flourishing in individuals undergoing maintenance hemodialysis in Shanghai: a Latent Profile Analysis.Frontiers in psychology · 2026Article
- Exploring Anxiety Triggers in Non-sedated Upper Gastrointestinal Endoscopy: A Prospective Analysis.Digestive diseases and sciences · 2025Observational
- Psychological Effects of Hemodialysis on Patients with Renal Failure: A Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Mental Health Symptoms and Receipt of Mental Health Care Among US Adults Diagnosed With Kidney Disease.Preventing chronic disease · 2025Article
- Alterations of serum metabolic profile in major depressive disorder: A case-control study in the Chinese population.World journal of psychiatry · 2025Article
- Relationship between renal function and cognitive impairment in patients with stable schizophrenia: a multicenter cross-sectional study.BMC psychiatry · 2025Article
- Early-stage chronic kidney disease as a risk factor for suicide: a nationwide observational cohort study.Journal of nephrology · 2025Observational
- Flourishing and its influencing factors among maintenance hemodialysis patients in Shanghai, China: a cross-sectional study.Frontiers in psychiatry · 2025Article
- Comparative psychological well-being evaluation among CKD patients on conservative therapy, dialysis, or kidney transplantation: a cross-sectional study.Frontiers in psychology · 2025Article
- A retrospective cohort study on the bidirectional association between depression and chronic kidney disease.Frontiers in nephrology · 2025Article
- Global trends and risk factors of chronic kidney disease in children and young adults from 1990 to 2021: a systematic analysis of the global burden of disease study 2021.Frontiers in public health · 2025Article
- Association between coexisting physical, cognitive, and social frailty and sarcopenia in patients undergoing maintenance hemodialysis.Frontiers in medicine · 2025Article
- Unhealthy lifestyle profile as a risk factor for poor quality of life and mental health in chronic kidney disease patients: a comparative case-control study.Frontiers in medicine · 2025Article
- Neuropsychiatric complications in chronic kidney disease: Role of gender, clinical, and sociodemographic factors.Journal of family medicine and primary care · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuropsychiatric conditions including depression, anxiety disorders, and cognitive impairment are prevalent in patients with chronic kidney disease (CKD). These conditions often make worse the quality of life and also lead to longer hospitalizations and higher mortality. Over the past decades, some hypotheses have tried to explain the connection between CKD and neuropsychiatric disorders. The most common hypothesis is based on the occurrence of cerebrovascular disease and accumulated uremic toxins in adult patients with CKD. However, the lack of a direct association between known vascular risk factors (e.g., diabetes and hypertension) with CKD-related cognitive deficits suggests that other mechanisms may also play a role in the pathophysiology shared by renal and neuropsychiatric diseases. This hypothesis is corroborated by the occurrence of neuropsychiatric comorbidities in pediatric patients with CKD preceding vascular damage, and the inconsistent findings on neuroprotective effects of antihypertensives. The aim of this narrative review was to summarize clinical evidence and potential mechanisms that links CKD and brain disorders, specifically in regard to cognitive impairment, anxiety, and depression.
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