Evidence map›Paper›PMID 31474862›Full record

ReviewFrontiers in pharmacology2019

microRNA Crosstalk Influences Epithelial-to-Mesenchymal, Endothelial-to-Mesenchymal, and Macrophage-to-Mesenchymal Transitions in the Kidney.

Swayam Prakash Srivastava, Ahmad Fahim Hedayat, Keizo Kanasaki, Julie E Goodwin

Erratum issuedOpen access · goldAbstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 73 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Current molecular medicine · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Epigenetic therapeutics attenuate kidney injury and fibrosis by restoring the expression of epigenetically reprogrammed fibrogenic genes and signaling pathways.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Construction of a Nomogram-Based Prediction Model for the Risk of Diabetic Kidney Disease in T2DM.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024
    Article
  19. Drugs for Diabetes: From Pharmacology to Clinical Application.Pharmaceuticals (Basel, Switzerland) · 2023
    Article
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Swayam Prakash SrivastavaDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, United States.
Ahmad Fahim HedayatDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, United States.
Keizo KanasakiInternal Medicine 1, Shimane University Faculty of Medicine, Izumo, Japan.
Julie E GoodwinDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, United States.
Yale University · USShimane University · JP

Funding

Endothelial glucocorticoid receptor suppresses vascular inflammationR01HL131952 · NHLBI · YALE UNIVERSITY · PI GOODWIN, JULIE · 2016 to 2025
$4.9M
NHLBI NIH HHS R01 HL131952
6 · The paper itself

Abstract

microRNAs (miRNAs) are small, non-coding nucleotides that regulate diverse biological processes. Altered microRNA biosynthesis or regulation contributes to pathological processes including kidney fibrosis. Kidney fibrosis is characterized by deposition of excess extracellular matrix (ECM), which is caused by infiltration of immune cells, inflammatory cells, altered chemokines, and cytokines as well as activation and accumulation of fibroblasts in the kidney. These activated fibroblasts can arise from epithelial cells

Indexed as

diabetic kidney diseaseendothelial-to-mesenchymal transitionepithelial-to-mesenchymal transitionkidney fibrosismacrophage-to-mesenchymal transitionmicroRNA crosstalkmicroRNAs

Identifiers

PMID31474862
PMCPMC6707424
OpenAlexW2963922316

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.