ReviewFrontiers in pharmacology2019
Levofloxacin: Insights Into Antibiotic Resistance and Product Quality.
Review in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- Mass Flux Analysis Reveals the Presence and Fate of Antimicrobials in Hospital Effluent, Wastewater Treatment Plant, and River Environments.Antibiotics (Basel, Switzerland) · 2026Article
- First Multi-Facility Antimicrobial Surveillance in Japanese Hospital Wastewater Reveals Spatiotemporal Trends and Source-Specific Environmental Loads.Antibiotics (Basel, Switzerland) · 2026Article
- Repurposing fluoroquinolones as cancer chemosensitizers: a way to overcome cancer therapeutic bottleneck.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Performance of a Pilot-Scale Continuous Flow Ozone-Based Hospital Wastewater Treatment System.Antibiotics (Basel, Switzerland) · 2023Article
- Comparison ofFrontiers in microbiology · 2023Article
- A pharmaceutical monitoring system to assess the quality of antituberculosis drug products used in Mauritania.PloS one · 2023Article
- Trends in counterfeit drugs and pharmaceuticals before and during COVID-19 pandemic.Forensic science international · 2022Review
- Robust antibacterial activity of functionalized carbon nanotube- levofloxacine conjugate based on in vitro and in vivo studies.Scientific reports · 2022Article
- Online Pharmacies Selling Prescription Drugs: Systematic Review.Pharmacy (Basel, Switzerland) · 2022Review
- A review and revisit of nanoparticles for antimicrobial drug delivery.Journal of medicine and life · 2022Review
- Effect of the Combination of Levofloxacin with Cationic Carbosilane Dendron and Peptide in the Prevention and Treatment ofPolymers · 2021Article
- Levofloxacin might be safe to use for OSCC patients.Medical oncology (Northwood, London, England) · 2021Article
- A systematic review of pharmaceutical price mark-up practice and its implementation.Exploratory research in clinical and social pharmacy · 2021Review
- How Safe are Fluoroquinolones for Diabetic Patients? A Systematic Review of Dysglycemic and Neuropathic Effects of Fluoroquinolones.Therapeutics and clinical risk management · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 8 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Counterfeit and substandard medicines are recognized as one of serious threats to public health. The product quality of antibacterial medicine will compromise patients' recovery and increase the chance of antibacterial resistance. The review aims to provide a summary of low quality levofloxacin issues and the risk factors as well as suggesting the aspects of product quality that need to be regulated strictly. Quality of the active ingredient, levofloxacin, has an important role to contribute to successful therapy. The poor quality of raw material, directly and indirectly, causes treatment failure as the presence of insufficient dose, mislabeled content, and poor dissolution characteristics can lead to lower bioavailability. Identifying and reporting these factors can potentially help in improving the quality of drug marketed in various developing countries and may also reduce the incidences of treatment failure. Dissolution test is used for testing the dissolution profiles and the rate of drug release from solid formulation such as oral formulations, thus providing information regarding the in vivo performance of a formulation and its bioequivalence. On the other hand, quality-testing procedures are used for comparing the quality of products.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.