Evidence map›Paper›PMID 31474749›Full record

ArticleCell death & disease2019

The effect of cysteine oxidation on DJ-1 cytoprotective function in human alveolar type II cells.

Karim Bahmed, Samia Boukhenouna, Loukmane Karim, Tessa Andrews, Jiusheng Lin, Robert Powers, Mark A Wilson, Chih-Ru Lin, Elise Messier, Nichole Reisdorph and 5 more

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
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  7. Article
  8. Article
  9. Review
  10. The Role of the Thioredoxin System in Brain Diseases.Antioxidants (Basel, Switzerland) · 2022
    Review
  11. Article
  12. Oxidation of DJ-1 Cysteines in Retinal Pigment Epithelium Function.International journal of molecular sciences · 2022
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Karim BahmedDepartment of Thoracic Medicine and Surgery, Temple University, Philadelphia, PA, 19140, USA.
Samia BoukhenounaDepartment of Thoracic Medicine and Surgery, Temple University, Philadelphia, PA, 19140, USA.
Loukmane KarimDepartment of Thoracic Medicine and Surgery, Temple University, Philadelphia, PA, 19140, USA.
Tessa AndrewsUniversity of Nebraska, Lincoln, NE, 68588, USA.
Jiusheng LinUniversity of Nebraska, Lincoln, NE, 68588, USA.
Robert PowersUniversity of Nebraska, Lincoln, NE, 68588, USA.
Mark A WilsonUniversity of Nebraska, Lincoln, NE, 68588, USA.
Chih-Ru LinDepartment of Thoracic Medicine and Surgery, Temple University, Philadelphia, PA, 19140, USA.
Elise MessierNational Jewish Health, Denver, CO, 80206, USA.
Nichole ReisdorphNational Jewish Health, Denver, CO, 80206, USA.
Roger L PowellNational Jewish Health, Denver, CO, 80206, USA.
Hsin-Yao TangThe Wistar Institute, Philadelphia, PA, 19104, USA.
Robert J MasonNational Jewish Health, Denver, CO, 80206, USA.
Gerard J CrinerDepartment of Thoracic Medicine and Surgery, Temple University, Philadelphia, PA, 19140, USA.
Beata KosmiderDepartment of Thoracic Medicine and Surgery, Temple University, Philadelphia, PA, 19140, USA. beata.kosmider@temple.edu.
Temple University · USUniversity of Nebraska–Lincoln · USNational Jewish Health · USUniversity of Colorado Denver · USThe Wistar Institute · US

Funding

Advancing Cancer Research through Comprehensive Proteomics and Metabolomics AnalysesR50CA221838 · NCI · WISTAR INSTITUTE · PI Hsin-Yao Tang · 2017 to 2026
$2.1M
DJ-1 pathway impairment in alveolar type II cells in emphysema.R01HL118171 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI KOSMIDER, BEATA · 2014 to 2018
$2.0M
Molecular Mechanisms of DiseaseT32GM107001 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI BECKER, DONALD F, BLACK, PAUL N. · 2015 to 2019
$1.0M
NCI NIH HHS R50 CA221838NHLBI NIH HHS R01 HL118171NIGMS NIH HHS T32 GM107001
6 · The paper itself

Abstract

DJ-1 is a multifunctional protein with cytoprotective functions. It is localized in the cytoplasm, nucleus, and mitochondria. The conserved cysteine residue at position 106 (Cys106) within DJ-1 serves as a sensor of redox state and can be oxidized to both the sulfinate (-SO

Indexed as

AgedAlveolar Epithelial CellsCell Line, TumorCysteineFemaleHumansMaleMiddle AgedOxidation-ReductionOxidative StressProtein Deglycase DJ-1TransfectionCysteinePARK7 protein, humanProtein Deglycase DJ-1

Identifiers

PMID31474749
PMCPMC6717737
OpenAlexW2970851789

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.