ArticleCell metabolism2019
Glutamate Signaling in Hepatic Stellate Cells Drives Alcoholic Steatosis.
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Article in Cell metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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58citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
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Who cites it
58 citing papers in PubMed, 94 citations in OpenAlex.
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- GLS1-RNA Polymerase II Axis Mediates Glutamine-Dependent Hepatoprotective Effects on Alcoholic Liver Disease in High-Protein Diets.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Alcohol-Induced Oxidative Stress and Gut-Liver-Brain Crosstalk: Expanding the Paradigm from ALD to MetALD.Antioxidants (Basel, Switzerland) · 2025Review
- Binge drinking triggers VGLUT3-mediated glutamate secretion and subsequent hepatic inflammation by activating mGluR5/NOX2 in Kupffer cells.Nature communications · 2025Article
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- Molecular mechanisms of alcohol-associated liver disease-ferroptosis and autophagy crosstalk.Molecular biology reports · 2025Review
- Inhibition of metabotropic glutamate receptor-5 alleviates hepatic steatosis by enhancing autophagyWorld journal of gastroenterology · 2025Article
- Elevated systemic total bile acids escalate susceptibility to alcohol-associated liver disease.iScience · 2024Article
- Cell-to-cell and organ-to-organ crosstalk in the pathogenesis of alcohol-associated liver disease.eGastroenterology · 2024Article
- Immunopathogenesis of liver fibrosis in steatotic liver disease.Clinical and molecular hepatology · 2024Article
- Linking fatty liver diseases to hepatocellular carcinoma by hepatic stellate cells.Journal of the National Cancer Center · 2024Review
- Cannabinoids and the Gastrointestinal Tract.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2023Review
- Atractylenolide III Ameliorates Bile Duct Ligation-Induced Liver Fibrosis by Inhibiting the PI3K/AKT Pathway and Regulating Glutamine Metabolism.Molecules (Basel, Switzerland) · 2023Article
- Unraveling the Emerging Niche Role of Hepatic Stellate Cell-derived Exosomes in Liver Diseases.Journal of clinical and translational hepatology · 2023Review
- Remodeling the hepatic fibrotic microenvironment with emerging nanotherapeutics: a comprehensive review.Journal of nanobiotechnology · 2023Review
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Authors and funding
24 authors at 7 institutions in 3 countries.
Won-Mook ChoiLaboratory of Liver Research, Graduate School of Medical Science and Engineering, KAIST, Daejeon 34141, Republic of Korea; Department of Gastroenterology, Liver Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea.
Hee-Hoon KimLaboratory of Liver Research, Graduate School of Medical Science and Engineering, KAIST, Daejeon 34141, Republic of Korea.
Myung-Ho KimLaboratory of Liver Research, Graduate School of Medical Science and Engineering, KAIST, Daejeon 34141, Republic of Korea.
Resat CinarLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
Hyon-Seung YiLaboratory of Liver Research, Graduate School of Medical Science and Engineering, KAIST, Daejeon 34141, Republic of Korea; Department of Internal Medicine, Chungnam National University, School of Medicine, Daejeon 35015, Republic of Korea.
Hyuk Soo EunLaboratory of Liver Research, Graduate School of Medical Science and Engineering, KAIST, Daejeon 34141, Republic of Korea; Department of Internal Medicine, Chungnam National University, School of Medicine, Daejeon 35015, Republic of Korea.
Seok-Hwan KimDepartment of Surgery, Chungnam National University, College of Medicine, Daejeon 35015, Republic of Korea.
Young Jae ChoiCollege of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea.
Young-Sun LeeLaboratory of Liver Research, Graduate School of Medical Science and Engineering, KAIST, Daejeon 34141, Republic of Korea; Department of Internal Medicine, Korea University College of Medicine, Seoul 08308, Republic of Korea.
So Yeon KimLaboratory of Liver Research, Graduate School of Medical Science and Engineering, KAIST, Daejeon 34141, Republic of Korea.
Wonhyo SeoLaboratory of Liver Research, Graduate School of Medical Science and Engineering, KAIST, Daejeon 34141, Republic of Korea; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
Jun-Hee LeeLaboratory of Liver Research, Graduate School of Medical Science and Engineering, KAIST, Daejeon 34141, Republic of Korea.
Young-Ri ShimLaboratory of Liver Research, Graduate School of Medical Science and Engineering, KAIST, Daejeon 34141, Republic of Korea.
Ye Eun KimLaboratory of Liver Research, Graduate School of Medical Science and Engineering, KAIST, Daejeon 34141, Republic of Korea.
Keungmo YangLaboratory of Liver Research, Graduate School of Medical Science and Engineering, KAIST, Daejeon 34141, Republic of Korea.
Tom RyuLaboratory of Liver Research, Graduate School of Medical Science and Engineering, KAIST, Daejeon 34141, Republic of Korea.
Jung Hwan HwangLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
Chul-Ho LeeLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
Hueng-Sik ChoiSchool of the Biological Sciences and Technology, Chonnam National University, Gwangju 61186, Republic of Korea.
Bin GaoLaboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
Won KimDepartment of Internal Medicine, Seoul Metropolitan Government, Seoul National University Boramae Medical Center, Seoul 07061, Republic of Korea.
Sang Kyum KimCollege of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea.
George KunosLaboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: george.kunos@nih.gov.
Won-Il JeongLaboratory of Liver Research, Graduate School of Medical Science and Engineering, KAIST, Daejeon 34141, Republic of Korea. Electronic address: wijeong@kaist.ac.kr.
Korea Advanced Institute of Science and Technology · KRNational Institutes of Health · USKorea Research Institute of Bioscience and Biotechnology · KRChonnam National University · KRChungnam National University · KRSeoul National University · KRUlsan College · KR
Funding
Endocannabinoids And Appetitive FunctionsZ01AA000350 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI KUNOS, GEORGE · 2001 to 2008
$2.1MIntramural NIH HHS Z01 AA000350Intramural NIH HHS Z99 AA999999
Abstract
Activation of hepatocyte cannabinoid receptor-1 (CB
Indexed as
AdultAgedAmino Acid Transport System y+AnimalsArachidonic AcidsEndocannabinoidsFatty Liver, AlcoholicFemaleGlutamic AcidGlyceridesHEK293 CellsHepatic Stellate CellsHepatocytesHep G2 CellsHumansLipogenesisAmino Acid Transport System y+Arachidonic AcidsCNR1 protein, humanCNR1 protein, mouseEndocannabinoidsGlutamic AcidGlyceridesglyceryl 2-arachidonateGRM5 protein, humanGrm5 protein, mouseReceptor, Cannabinoid, CB1Receptor, Metabotropic Glutamate 5SLC7A11 protein, humanSlc7a11 protein, mouse2-arachidonoylglycerolalcoholic liver diseasecannabinoid receptormetabotrophic glutamate receptor 5Nrf2transsulfuration pathwayxCT
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