ArticleCurrent biology : CB2019
Recurrent Circuitry Sustains Drosophila Courtship Drive While Priming Itself for Satiety.
Article in Current biology : CB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Cell-type-resolved RNA-seq reveals molecular signatures of sexual experience inNAR genomics and bioinformatics · 2026Article
- Fertility reversibly modulatesbioRxiv : the preprint server for biology · 2026Article
- Behavioral devaluation by local resistance to dopamine.Nature neuroscience · 2025Article
- A neural circuit for context-dependent multimodal signaling in Drosophila.Nature communications · 2025Article
- Temperature-dependent modulation of light-induced circadian responses in Drosophila melanogaster.The EMBO journal · 2025Article
- Article
- The foraging gene coordinates brain and heart networks to modulate socially cued interval timing in Drosophila.PLoS genetics · 2025Article
- Comparative Perspectives on Neuropeptide Function and Social Isolation.Biological psychiatry · 2025Review
- Connectomic analysis of taste circuits in Drosophila.Scientific reports · 2025Article
- Mating proximity blinds threat perception.Nature · 2024Article
- Article
- Long-term neuropeptide modulation of female sexual drive via the TRP channel inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Peer-induced quiescence of maleFrontiers in behavioral neuroscience · 2024Article
- TheProceedings of the National Academy of Sciences of the United States of America · 2023Article
- The neuropeptide drosulfakinin enhances choosiness and protects males from the aging effects of social perception.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Asexuality in Drosophila juvenile males is organizational and independent of juvenile hormone.EMBO reports · 2023Article
- Persistent modulatory actions and task switching in the feeding network of Aplysia.Current opinion in neurobiology · 2023Review
- Intense light unleashes male-male courtship behaviour in wild-typeOpen biology · 2023Article
- Many faces of sleep regulation: beyond the time of day and prior wake time.The FEBS journal · 2023Review
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Abstract
Motivations intensify over hours or days, promoting goals that are achieved in minutes or hours, causing satiety that persists for hours or days. Here we develop Drosophila courtship as a system to study these long-timescale motivational dynamics. We identify two neuronal populations engaged in a recurrent excitation loop, the output of which elevates a dopamine signal that increases the propensity to court. Electrical activity within the recurrent loop accrues with abstinence and, through the activity-dependent transcription factor CREB2, drives the production of activity-suppressing potassium channels. Loop activity is decremented by each mating to reduce subsequent courtship drive, and the inhibitory loop environment established by CREB2 during high motivation slows the reaccumulation of activity for days. Computational modeling reproduces these behavioral and physiological dynamics, generating predictions that we validate experimentally and illustrating a causal link between the motivation that drives behavior and the satiety that endures after goal achievement.
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