ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2019
Adipose tissue quantification and primary graft dysfunction after lung transplantation: The Lung Transplant Body Composition study.
Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Incidence of primary graft dysfunction and its associated risk factors after lung transplantation: a systematic review and meta-analysis.Surgery today · 2025Pooled it
- CT-derived skeletal muscle predicts lung transplant approval.JHLT open · 2026Article
- The prognostic role of preoperative subcutaneous adipose tissue measurement in lung transplantation.BMC pulmonary medicine · 2026Article
- Knowledge structure and academic influence in lung transplantation: a systematically bibliometric analysis of highly cited documents and multi-perspective extensive review.Journal of thoracic disease · 2026Article
- Review
- Predicting Primary Graft Dysfunction in Systemic Sclerosis Lung Transplantation Using Machine-Learning and CT Features.Clinical transplantation · 2025Article
- Tolerability and Effectiveness of Glucagon-Like Peptide-1 Receptor Agonists in Lung Transplant Recipients: A Single Center Report.Transplantation proceedings · 2025Article
- Early serum biomarkers to characterise different phenotypes of primary graft dysfunction after lung transplantation: a systematic scoping review.ERJ open research · 2024Article
- Adipose Tissue Segmentation after Lung Slice Localization in Chest CT Images Based on ConvBiGRU and Multi-Module UNet.Biomedicines · 2024Article
- Nonlinear associations between computed tomography-measures of adiposity and long pentraxin-3 in the Multi-Ethnic Study of Atherosclerosis.Obesity science & practice · 2024Article
- Accuracy and Reproducibility of Automated Measurement of Body Composition: A Lung Transplant Body Composition Cohort Study.Annals of the American Thoracic Society · 2023Article
- Development of the Lung Transplant Frailty Scale (LT-FS).The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2023Article
- Body Mass Index and Cause-Specific Mortality after Lung Transplantation in the United States.Annals of the American Thoracic Society · 2023Article
- Acute Lung Injury in aortic dissection : new insights in anesthetic management strategies.Journal of cardiothoracic surgery · 2023Review
- Article
- The Intersection of Aging and Lung Transplantation: its Impact on Transplant Evaluation, Outcomes, and Clinical Care.Current transplantation reports · 2022Article
- Obesity-related IL-18 Impairs T-Regulatory Cell Function and Promotes Lung Ischemia-Reperfusion Injury.American journal of respiratory and critical care medicine · 2021Article
- Anesthetic considerations in lung transplantation: past, present and future.Journal of thoracic disease · 2021Review
- Primary graft dysfunction: what we know.Journal of thoracic disease · 2021Review
- Adiposity and Interstitial Lung Abnormalities in Community-Dwelling Adults: The MESA Cohort Study.Chest · 2021Article
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Authors and funding
33 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundObesity is associated with an increased risk of primary graft dysfunction (PGD) after lung transplantation. The contribution of specific adipose tissue depots is unknown.
methodsWe performed a prospective cohort study of adult lung transplant recipients at 4 U.S. transplant centers. We measured cross-sectional areas of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) on chest and abdominal computed tomography (CT) scans and indexed each measurement to height.
resultsA total of 262 and 117 subjects had available chest CT scans and underwent protocol abdominal CT scans, respectively. In the adjusted models, a greater abdominal SAT index was associated with an increased risk of PGD (odds ratio 1.9, 95% CI 1.02-3.4, p = 0.04) but not with survival time. VAT indices were not associated with PGD risk or survival time. A greater abdominal SAT index correlated with greater pre- and post-transplant leptin (r = 0.61, p < 0.001, and r = 0.44, p < 0.001), pre-transplant IL-1RA (r = 0.25, p = 0.04), and post-transplant ICAM-1 (r = 0.25, p = 0.04). We identified 3 latent patterns of adiposity. The class defined by high thoracic and abdominal SAT had the greatest risk of PGD.
conclusionsSubcutaneous, but not visceral, adiposity is associated with an increased risk of PGD after lung transplantation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.