ArticleAmerican journal of human genetics2019
Distinct HLA Associations with Rheumatoid Arthritis Subsets Defined by Serological Subphenotype.
Erratum issuedOpen access · hybridAbstract read
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Article in American journal of human genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 1 of them a synthesis that pooled it.
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23citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Molecular endotypes in musculoskeletal disorders: a systematic review.BMC musculoskeletal disorders · 2026Pooled it
- Presence and reactivities of antibodies directed to citrullinated peptides in a Swedish JIA cohort.Pediatric rheumatology online journal · 2025Article
- Autoantibodies as prognostic markers in rheumatoid arthritis.Journal of translational autoimmunity · 2025Review
- Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis.The Journal of clinical investigation · 2025Article
- The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: a comprehensive review.Clinical rheumatology · 2025Review
- Revisiting the Link Between HLA-DRB1 Alleles and Autoantibodies in Rheumatoid Arthritis: Association of non-Shared Epitope Alleles *09 and *15 With High Levels of Anti-Citrullinated Peptide/Protein Antibodies.ACR open rheumatology · 2025Article
- Article
- Blockade of IL-1 family cytokines in the treatment of rheumatoid arthritis.Frontiers in pharmacology · 2025Review
- Identification of a regulatory pathway governing TRAF1 via an arthritis-associated non-coding variant.Cell genomics · 2023Article
- Microbiota-assisted therapy for systemic inflammatory arthritis: advances and mechanistic insights.Cellular and molecular life sciences : CMLS · 2022Review
- Distal Interphalangeal Joint Involvement May Be Associated with Disease Activity and Affected Joint Distribution in Rheumatoid Arthritis.Journal of clinical medicine · 2022Article
- Assessment of HLA-B genetic variation with an HLA-B leader tool and implications in clinical transplantation.Blood advances · 2022Article
- A Roadmap for Investigating Preclinical Autoimmunity Using Patient-Oriented and Epidemiologic Study Designs: Example of Rheumatoid Arthritis.Frontiers in immunology · 2022Review
- Genetics of rheumatoid arthritis.Seminars in immunopathology · 2022Review
- The Genetic, Environmental, and Immunopathological Complexity of Autoantibody-Negative Rheumatoid Arthritis.International journal of molecular sciences · 2021Review
- Biological classification of childhood arthritis: roadmap to a molecular nomenclature.Nature reviews. Rheumatology · 2021Review
- Common genetic variants in PRRC2A are associated with both neuromyelitis optica spectrum disorder and multiple sclerosis in Han Chinese population.Journal of neurology · 2021Article
- Influence of the shared epitope on the elicitation of experimental autoimmune arthritis biomarkers.PloS one · 2021Article
- In Rheumatoid Arthritis Patients, HLA-DRB1*04:01 and Rheumatoid Nodules Are Associated With ACPA to a Particular Fibrin Epitope.Frontiers in immunology · 2021Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
20 authors at 9 institutions in 6 countries.
Chikashi TeraoDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Clinical Research Center, Shizuoka General Hospital, Shizuoka 420-8527, Japan; The Department of Applied Genetics, The School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan.
Boel BrynedalDepartment of Translational Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Solna, 171 76 Stockholm, Sweden; Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, 171 76 Stockholm, Sweden.
Zuomei ChenDepartment of Translational Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Solna, 171 76 Stockholm, Sweden.
Xia JiangDepartment of Translational Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Solna, 171 76 Stockholm, Sweden.
Helga WesterlindDepartment of Translational Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Solna, 171 76 Stockholm, Sweden.
Monika HanssonDivision of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, 171 76 Stockholm, Sweden.
Per-Johan JakobssonDivision of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, 171 76 Stockholm, Sweden.
Karin LundbergDivision of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, 171 76 Stockholm, Sweden.
Karl SkrinerCharité Universitätsmedizin Berlin, Humboldt University of Berlin, 10117 Berlin, Germany.
Guy SerreUDEAR, UMRS 1056 Inserm - Université Toulouse III, Toulouse, France.
Johan RönnelidDepartment of Immunology, Genetics and Pathology, Uppsala University, 751 85 Uppsala, Sweden.
Linda Mathsson-AlmDepartment of Immunology, Genetics and Pathology, Uppsala University, 751 85 Uppsala, Sweden; Thermo Fischer Scientific Uppsala, 751 37 Uppsala, Sweden.
Mikael BrinkDepartment of Public Health and Clinical Medicine/Rheumatology, University of Umeå, 90187 Umeå, Sweden.
Solbritt Rantapää DahlqvistDepartment of Public Health and Clinical Medicine/Rheumatology, University of Umeå, 90187 Umeå, Sweden.
Leonid PadyukovDivision of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, 171 76 Stockholm, Sweden.
Peter K GregersenRobert S. Boas Center for Genomics and Human Genetics, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA.
Anne BartonVersus Arthritis Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, Oxford Road, Manchester M13 9PT, UK.
Lars AlfredssonDepartment of Translational Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Solna, 171 76 Stockholm, Sweden.
Lars KlareskogDivision of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, 171 76 Stockholm, Sweden. Electronic address: lars.klareskog@ki.se.
Soumya RaychaudhuriDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA; Versus Arthritis Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, Oxford Road, Manchester M13 9PT, UK; Center for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: soumya@broadinstitute.org.
Karolinska University Hospital · SEKarolinska Institutet · SEBroad Institute · USUmeå University · SEUppsala University · SEFeinstein Institute for Medical Research · USHumboldt-Universität zu Berlin · DEManchester Academic Health Science Centre · GBUniversité Toulouse III - Paul Sabatier · FR
Funding
Discovery and Functional Impact of Common and Rare Variants in RAR01AR063759 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Soumya Raychaudhuri · 2013 to 2026
$5.4MRA-SLE Molecular Deconstruction Leadership CenterUH2AR067677 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI BRENNER, MICHAEL B., RAYCHAUDHURI, SOUMYA · 2014 to 2020
$4.3MFunctionally specialized components of disease heritability in ENCODE dataU01HG009379 · NHGRI · HARVARD SCHOOL OF PUBLIC HEALTH · PI PRICE, ALKES L, RAYCHAUDHURI, SOUMYA · 2017 to 2021
$2.5MNHGRI NIH HHS U01 HG009379NIAMS NIH HHS R01 AR063759NIAMS NIH HHS UH2 AR067677
Abstract
Rheumatoid arthritis (RA) is the most common immune-mediated arthritis. Anti-citrullinated peptide antibodies (ACPA) are highly specific to RA and assayed with the commercial CCP2 assay. Genetic drivers of RA within the MHC are different for CCP2-positive and -negative subsets of RA, particularly at HLA-DRB1. However, aspartic acid at amino acid position 9 in HLA-B (B
Indexed as
PhenotypeArthritis, RheumatoidCase-Control StudiesGenetic Predisposition to DiseaseHLA AntigensHumansHLA Antigenscitrullinated peptidesgeneticsHLAmajor histocompatability complexMHCrheumatoid arthritis
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