Evidence map›Paper›PMID 31473908›Full record

ArticleMycopathologia2019

Multifunction of the ER P-Type Calcium Pump Spf1 During Hyphal Development in Candida albicans.

Qilin Yu, Tianyu Ma, Congcong Ma, Biao Zhang, Mingchun Li

Abstract read
PubMed Publisher
In one paragraph

Article in Mycopathologia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. The Role of Secretory Pathways inJournal of fungi (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Qilin YuKey Laboratory of Molecular Microbiology and Technology, Department of Microbiology, Ministry of Education, College of Life Science, Nankai University, Tianjin, 300071, People's Republic of China.
Tianyu MaKey Laboratory of Molecular Microbiology and Technology, Department of Microbiology, Ministry of Education, College of Life Science, Nankai University, Tianjin, 300071, People's Republic of China.
Congcong MaKey Laboratory of Molecular Microbiology and Technology, Department of Microbiology, Ministry of Education, College of Life Science, Nankai University, Tianjin, 300071, People's Republic of China.
Biao ZhangTianjin University of Chinese Traditional Medicine, Tianjin, People's Republic of China.
Mingchun LiKey Laboratory of Molecular Microbiology and Technology, Department of Microbiology, Ministry of Education, College of Life Science, Nankai University, Tianjin, 300071, People's Republic of China. nklimingchun@163.com.ORCID http://orcid.org/0000-0001-5298-8784
Nankai University · CNTianjin University of Traditional Chinese Medicine · CN

Funding

National Natural Science Foundation of China 31870139, 81873961, 31670146Natural Science Foundation of Tianjin City (CN) 17JCZDJC33300
6 · The paper itself

Abstract

Candida albicans is one of the most important fungal pathogens. Hyphal development is required for the virulence of this pathogen. Our previous study has revealed that Spf1, an ER P-type calcium pump, plays an important role in hyphal development. However, the detailed mechanisms by which this protein functions in this process remain to be investigated. In this study, we found that loss of Spf1 led to decreased growth biomass under the hypha-inducing condition, suggesting a role of this protein in maintaining hyphal growth rate. Actin staining further revealed that the spf1Δ/Δ mutant showed attenuated tip-localization of actin patches and the defect in transport of both the chitin synthase Chs3 and the hypha-related factor Hwp1, implying that Spf1 functions in polarized growth of the hyphae by regulating actin organization and consequent polarized transport of morphogenesis-associated factors. Moreover, deletion of SPF1 led to abnormal vacuolar morphology under the hypha-inducing condition, which may also contribute to the defect of hyphal development in the spf1Δ/Δ mutant. This study revealed the pleiotropic role of Spf1-regulated calcium homeostasis in controlling hyphal development in C. albicans.

Indexed as

ATP-Binding Cassette TransportersCalciumCandida albicansGene DeletionHyphaeATP-Binding Cassette TransportersCalciumActin patchCandida albicansERHyphal developmentPolarized growthSpf1

Identifiers

PMID31473908
OpenAlexW2970910192

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.