ArticleJournal of gastroenterology2020
Natural history of asymptomatic bile duct stones and association of endoscopic treatment with clinical outcomes.
Article in Journal of gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 5 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 5 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Is it Safe to Perform Concomitant Cholecystectomy in Patients With Confirmed Gallbladder Disease Undergoing Metabolic and Bariatric Surgery? An Updated Meta-Analysis.Obesity surgery · 2025Pooled it
- Comparative Risks of Post-ERCP Adverse Events in Patients with Asymptomatic and Symptomatic Choledocholithiasis: A Systematic Review and Meta-Analysis.Digestive diseases and sciences · 2024Pooled it
- Prophylactic cholecystectomy offers best outcomes following ERCP clearance of common bile duct stones: a meta-analysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023Pooled it
- Selective intraoperative cholangiography should be considered over routine intraoperative cholangiography during cholecystectomy: a systematic review and meta-analysis.Surgical endoscopy · 2022Pooled it
- The Safety and Necessity of Concomitant Cholecystectomy During Bariatric Surgery in Patients with Obesity: a Systematic Review and Meta-analysis.Obesity surgery · 2021Pooled it
- First Case Report of Triple Recurrent Cholangitis of "Coildocholithiasis," Following Hepatic Artery Pseudoaneurysm Embolization.DEN open · 2027Article
- Surgical Management of Choledocholithiasis in a Patient After Bariatric Surgery at a Rural Hospital.Cureus · 2026Article
- Comparative Outcomes of Endoscopic Treatment for Symptomatic and Asymptomatic Common Bile Duct Stones in the Elderly: A Propensity Score-Based Cohort Analysis.Journal of hepato-biliary-pancreatic sciences · 2026Article
- Article
- Safety and feasibility of omitting routine endoscopic nasobiliary drainage after ERCP for common bile duct stones: a prospective comparative study.BMC surgery · 2026Article
- Risk Factors and Predictive Modeling of Occult Choledocholithiasis in Patients with Cholecystolithiasis.Gastroenterology research and practice · 2026Article
- Evolving Strategies for the Optimal Management of Common Bile Duct Stones.Gut and liver · 2025Review
- Unsedated emergent ERCP is feasible and efficient for acute cholangitis in old patients over 80 years.Surgical endoscopy · 2025Article
- Feasibility of cholecystectomy in patients with silent common bile duct stones cohort prospective single arm multicentre study.BMC gastroenterology · 2025Observational
- Common bile duct exploration with choledochotomy and primary repair during pregnancy: Case Report.Frontiers in medicine · 2025Article
- Synergistic effect of independent risk factors for post-endoscopic retrograde cholangiopancreatography pancreatitis: a multicenter retrospective study in Japan.Clinical endoscopy · 2024Article
- Prospective study on planned biliary stent placement to treat small common bile duct stones.JGH open : an open access journal of gastroenterology and hepatology · 2024Article
- Non-interventional Management of Asymptomatic Diminutive Choledocholithiasis Versus Endoscopic Extraction in Consecutive Patients.Digestive diseases and sciences · 2023Article
- Evidence-based clinical practice guidelines for cholelithiasis 2021.Journal of gastroenterology · 2023Review
- Epidemiology and outcomes of choledocholithiasis and cholangitis in the United States: trends and urban-rural variations.BMC gastroenterology · 2023Article
Corrections and comments
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Authors and funding
19 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDue to increasing opportunities for abdominal imaging studies, bile duct stones are occasionally diagnosed without any symptoms. However, there has been no consensus on the management of asymptomatic bile duct stones. We conducted a retrospective longitudinal cohort study to investigate the natural history of asymptomatic bile duct stones and clinical outcomes according to the timing of endoscopic removal.
methodsWe identified consecutive patients who were diagnosed with asymptomatic common bile duct stones and categorized into those who were followed up with stones in situ (wait-and-see group) and those who received early endoscopic stone removal (intervention group). Cumulative incidence functions of biliary complications were estimated and compared between the groups.
resultsWe included 191 patients (114 patients in the wait-and-see group and 77 patients in the intervention group). In the wait-and-see group, the cumulative incidence of biliary complications was 6.1% at 1 year, 11% at 3 years, and 17% at 5 years. Asymptomatic disappearance of stones was observed in 22 patients (19%). Procedure-related adverse events of early endoscopic stone removal of asymptomatic stones were observed in 25 (32%) patients including 4 (5.2%) with severe pancreatitis. The cumulative incidence function of biliary complications did not differ by treatment strategies (P = 0.55).
conclusionsBiliary complications occurred in a substantial proportion of patients with asymptomatic bile duct stones, but early endoscopic removal appeared to have little effect on the prevention of further biliary complications. Given the risk of procedure-related pancreatitis, the wait-and-see strategy may become a management option of asymptomatic stones.
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