Evidence map›Paper›PMID 31473770›Full record

ArticleCellular and molecular life sciences : CMLS2020

Group 1 metabotropic glutamate receptors trigger glutamate-induced intracellular Ca

Sharon Negri, Pawan Faris, Giorgia Pellavio, Laura Botta, Matteo Orgiu, Greta Forcaia, Giulio Sancini, Umberto Laforenza, Francesco Moccia

Open access · greenAbstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. CaBiomedicines · 2025
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Lysosomal TRPML1 triggers global CaFrontiers in physiology · 2024
    Article
  16. Cracking the Endothelial Calcium (CaInternational journal of molecular sciences · 2023
    Review
  17. Article
  18. Putative neurochemical and cell type contributions to hemodynamic activity in the rodent caudate putamen.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Sharon NegriLaboratory of General Physiology, Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, Via Forlanini 6, 27100, Pavia, Italy.
Pawan FarisLaboratory of General Physiology, Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, Via Forlanini 6, 27100, Pavia, Italy.
Giorgia PellavioHuman Physiology Unit, Department of Molecular Medicine, University of Pavia, Pavia, Italy.
Laura BottaLaboratory of General Physiology, Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, Via Forlanini 6, 27100, Pavia, Italy.
Matteo OrgiuLaboratory of General Physiology, Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, Via Forlanini 6, 27100, Pavia, Italy.
Greta ForcaiaDepartment of Experimental Medicine, University of Milano-Bicocca, Monza, Italy.
Giulio SanciniDepartment of Experimental Medicine, University of Milano-Bicocca, Monza, Italy.
Umberto LaforenzaHuman Physiology Unit, Department of Molecular Medicine, University of Pavia, Pavia, Italy.
Francesco MocciaLaboratory of General Physiology, Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, Via Forlanini 6, 27100, Pavia, Italy. francesco.moccia@unipv.it.ORCID http://orcid.org/0000-0003-0010-0098
University of Pavia · ITUniversity of Milano-Bicocca · IT

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca Dipartimenti di Eccellenza Program (2018-2022)Università degli Studi di Pavia Fondo Ricerca Giovani
6 · The paper itself

Abstract

Neurovascular coupling (NVC) is the mechanism whereby an increase in neuronal activity causes an increase in local cerebral blood flow (CBF) to ensure local supply of oxygen and nutrients to the activated areas. The excitatory neurotransmitter glutamate gates post-synaptic N-methyl-D-aspartate receptors to mediate extracellular Ca

Indexed as

Calcium SignalingNeurovascular CouplingBrainCell LineEndothelial CellsGlutamic AcidHumansMicrovesselsNitric OxideReceptors, Metabotropic GlutamateGlutamic Acidmetabotropic glutamate receptor type 1Nitric OxideReceptors, Metabotropic GlutamateBrain microvascular endothelial cellsCa2+ signalingGlutamateGroup 1 metabotropic glutamate receptorsNeurovascular couplingNitric oxide

Identifiers

PMID31473770
PMCPMC11104941
OpenAlexW2970002377

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.