SynthesisBMJ supportive & palliative care2019
Lung cancer and end-of-life care: a systematic review and thematic synthesis of aggressive inpatient care.
Synthesis in BMJ supportive & palliative care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Which factors influence the quality of end-of-life care in interstitial lung disease? A systematic review with narrative synthesis.Palliative medicine · 2022Pooled it
- Comparison of Two Methods for Implementing Comfort Care Order Sets in the Inpatient Setting: a Cluster Randomized Trial.Journal of general internal medicine · 2021Trial
- The Influence of Specialist Palliative Care in Aggressive End of Life Management of Patients with Advanced Cancer.Zdravstveno varstvo · 2026Article
- Examining inpatient chemotherapy utilization among patients with cancer and impact on outcomes.The oncologist · 2025Article
- Cancer care at the end of life: system-wide expenditure in a national health service.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Dual balanced augmented topological noncoding RNA disease triplet association in heterogeneous graphs.Briefings in bioinformatics · 2025Article
- Cost Disparities with Age in the Treatment of Advanced Non-Small-Cell Lung Cancer (NSCLC) in Ontario, Canada.Current oncology (Toronto, Ont.) · 2025Article
- Trajectory of quality of life among patients with cancer at the end of life: a longitudinal survey study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Scoping review of anticancer drug utilization in lung cancer patients at the end of life.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Article
- Associations between palliative-care consultations and end-of-life quality in cancer patients' last 6 months.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Systemic Anticancer Therapy and Overall Survival in Patients With Very Advanced Solid Tumors.JAMA oncology · 2024Article
- Racial and Ethnic Disparities in Intensity of Care at the End of Life for Patients With Lung Cancer: A 13-Year Population-Based Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Article
- Anticancer therapy at end-of-life: A retrospective cohort study.Acta oncologica (Stockholm, Sweden) · 2024Article
- Prevalence of aggressive care among patients with cancer near the end of life: a systematic review and meta-analysis.EClinicalMedicine · 2024Article
- Aggressive End-of-Life Care and Caregiver Satisfaction for Patients With Advanced Cancer.Western journal of nursing research · 2024Article
- End-of-Life Systemic Oncologic Treatment in the Immunotherapy Era: The Role of Race, Insurance, and Practice Setting.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023Article
- Respecting Faith, Hope, and Miracles in African American Christian Patients at End-of-Life: Moving from Labeling Goals of Care as "Aggressive" to Providing Equitable Goal-Concordant Care.Journal of racial and ethnic health disparities · 2023Article
- Advanced Care Planning for Hospitalized Patients Following Clinician Notification of Patient Mortality by a Machine Learning Algorithm.JAMA network open · 2023Article
- The Effect of Timeliness of Care on Lung Cancer Survival - A Population-Based Approach.Annals of global health · 2023Article
- End-of-life care trajectories among older adults with lung cancer.Journal of geriatric oncology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesDespite recent advances in thoracic oncology, most patients with metastatic lung cancer die within months of diagnosis. Aggressiveness of their end-of-life (EOL) care has been the subject of numerous studies. This study was undertaken to evaluate the literature on aggressive inpatient EOL care for lung cancer and analyse the evolution of its aggressiveness over time.
methodsA systematic international literature search restricted to English-language publications used terms associated with aggressiveness of care, EOL and their synonyms. Two independent researchers screened for eligibility and extracted all data and another a random 10% sample of the abstracts. Electronic Medline and Embase databases were searched (2000-20 September 2018). EOL-care aggressiveness was defined as follows: 1) chemotherapy administered during the last 14 days of life (DOL) or new chemotherapy regimen during the last 30 DOL; 2) >2 emergency department visits; 3) >1 hospitalisation during the last 30 DOL; 4) ICU admission during the last 30 DOL and 5) palliative care started <3 days before death.
resultsAmong the 150 articles identified, 42 were retained for review: 1 clinical trial, 3 observational cohorts, 21 retrospective analyses and 17 administrative data-based studies. The percentage of patients subjected to aggressive therapy seems to have increased over time. Early management by palliative care teams seems to limit aggressive care.
conclusionsOur analysis indicated very frequent aggressive EOL care for patients with lung cancer, regardless of the definition used. The extent of that aggressiveness and its impact on healthcare costs warrant further studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.