ArticleBMJ open2019
C reactive protein level as a marker for dyslipidaemia, diabetes and metabolic syndrome: results from the Korea National Health and Nutrition Examination Survey.
Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
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- Systemic immune-inflammation index as a novel biomarker for metabolic syndrome: A systematic review and meta-analysis.Medicine · 2026Pooled it
- Can biomarkers be used to improve diagnosis and prediction of metabolic syndrome in childhood cancer survivors? A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021Pooled it
- The Association Between Serum C-Reactive Protein Levels and Body Fat Parameters: Results from the Korean National Health and Nutrition Examination Survey.Medicina (Kaunas, Lithuania) · 2026Article
- Diet Quality and Advanced Periodontitis in Relation to Serum CRP Levels: An 11-Year Follow-Up Study.Food science & nutrition · 2026Article
- Health-related quality of life in women with normogonadotropic ovulatory dysfunction: a prospective cohort study.Frontiers in global women's health · 2026Article
- Relationship between RAR and the risk of osteoarthritis: a comprehensive analysis based on NHANES data (1999-2018).Journal of orthopaedics · 2025Article
- Non-linear correlation between the ratio of high-density lipoprotein cholesterol to C-reactive protein and all-cause mortality in adults: an extensive study based on nationwide data.Population health metrics · 2025Article
- A machine learning-based framework for predicting metabolic syndrome using serum liver function tests and high-sensitivity C-reactive protein.Scientific reports · 2025Article
- Assessing Causality Between Endocrine, Nutritional, and Metabolic Disease and Pulmonary Tuberculosis: A Mendelian Randomization Study.Health science reports · 2025Article
- Non-linear association of a novel inflammation-lipid composite marker CRP/HDL with insulin resistance and type 2 diabetes: findings from a comprehensive national cross-sectional study.Diabetology & metabolic syndrome · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- The value of growth differentiation factor 15 as a biomarker for peripheral artery disease in diabetes patients.Diabetology & metabolic syndrome · 2025Article
- Low-Level Viremia as an Independent Risk Factor for Metabolic Syndrome in People Living with HIV Receiving Antiretroviral Therapy: A 6-Year Retrospective Cohort Study.Infection and drug resistance · 2025Article
- Toxicity Profile ofBiochemistry research international · 2025Article
- Biomarkers and Seaweed-Based Nutritional Interventions in Metabolic Syndrome: A Comprehensive Review.Marine drugs · 2024Review
- Impact of high-sensitivity C-reactive protein on metabolic syndrome in an elderly population: Findings from a hospital-based cross-sectional study in J&K, India.Journal of family medicine and primary care · 2024Article
- Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort.iScience · 2024Article
- Emerging Perspectives on the Set of Conditions That Lead to the Emergence of Metabolic Syndrome.Journal of personalized medicine · 2023Review
- Exploring regression dilution bias using repeat measurements of 2858 variables in ≤49 000 UK Biobank participants.International journal of epidemiology · 2023Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePlasma C reactive protein (CRP) is a marker of inflammation, and increased plasma CRP is reported in many diseases, including cardiovascular disease, diabetes, metabolic syndrome, arthritis and malignancies. The aim of the study was to evaluate the association between plasma CRP levels and cardiovascular disease, metabolic syndrome, malignancies and other comorbidities.
designA retrospective, cross-sectional survey study.
settingLarge population survey in Korea.
methodsA total of 5887 (weighted n=40 251 868) participants aged 19 years or older from the 2016 Korea National Health and Nutrition Examination Survey were included for analysis. Weighted prevalence and OR of comorbidities were analysed according to the continuous variable of log plasma high-sensitivity CRP levels.
resultsThe mean age was 46.7±0.37 years and the median plasma CRP was 0.58 mg/L (IQR 0.36-1.09). The mean plasma CRP levels were higher in participants with cardiovascular diseases and cardiovascular risk factors, osteoarthritis, rheumatoid arthritis, pulmonary tuberculosis, and several cancers, including gastric, colon, breast and cervix, than in the general population. In the multivariable analysis, plasma CRP concentration was associated with increased prevalence of hypertriglyceridaemia (OR 1.157, 95% CI 1.040 to 1.287, p=0.007), diabetes (OR 1.204, 95% CI 1.058 to 1.371, p=0.005) and metabolic syndrome (OR 1.228, 95% CI 1.112 to 1.357, p<0.001) after adjustment for socioeconomic and lifestyle characteristics. There was no significant association between plasma CRP level and cancers.
conclusionPlasma CRP was associated with an increased risk of dyslipidaemia, diabetes and metabolic syndrome in the general population.
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