Evidence map›Paper›PMID 31473301›Full record

SynthesisNeuroscience and biobehavioral reviews2019

Effects of online repetitive transcranial magnetic stimulation (rTMS) on cognitive processing: A meta-analysis and recommendations for future studies.

Lysianne Beynel, Lawrence G Appelbaum, Bruce Luber, Courtney A Crowell, Susan A Hilbig, Wesley Lim, Duy Nguyen, Nicolas A Chrapliwy, Simon W Davis, Roberto Cabeza and 2 more

Abstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neuroscience and biobehavioral reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lysianne BeynelDepartments of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, United States.
Lawrence G AppelbaumDepartments of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, United States.
Bruce LuberNoninvasive Neuromodulation Unit, Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States.
Courtney A CrowellDepartments of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, United States.
Susan A HilbigDepartments of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, United States.
Wesley LimDepartments of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, United States.
Duy NguyenDepartments of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, United States.
Nicolas A ChrapliwyDepartments of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, United States.
Simon W DavisDepartment of Neurology, Duke University School of Medicine, Durham, NC, United States.
Roberto CabezaCenter for Cognitive Neuroscience, Duke University, Durham, NC, United States.
Sarah H LisanbyDepartments of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, United States; Noninvasive Neuromodulation Unit, Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States.
Zhi-De DengDepartments of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, United States; Noninvasive Neuromodulation Unit, Experimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States. Electronic address: zhi-de.deng@nih.gov.

Funding

Non-invasive Neuromodulation Unit (NNU)ZIAMH002955 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI ZARATE, CARLOS · 2016 to 2025
$40.3M
Using fMRI-guided TMS to increase central executive function in older adults - Administrative SupplementU01AG050618 · NIA · DUKE UNIVERSITY · PI APPELBAUM, LAWRENCE G., CABEZA, ROBERTO · 2016 to 2019
$2.3M
Intramural NIH HHS ZIA MH002955NIA NIH HHS U01 AG050618
6 · The paper itself

Abstract

Online repetitive transcranial magnetic stimulation (rTMS), applied while subjects are performing a task, is widely used to disrupt brain regions underlying cognition. However, online rTMS has also induced "paradoxical enhancement". Given the rapid proliferation of this approach, it is crucial to develop a better understanding of how online stimulation influences cognition, and the optimal parameters to achieve desired effects. To accomplish this goal, a quantitative meta-analysis was performed with random-effects models fitted to reaction time (RT) and accuracy data. The final dataset included 126 studies published between 1998 and 2016, with 244 total effects for reaction times, and 202 for accuracy. Meta-analytically, rTMS at 10 Hz and 20 Hz disrupted accuracy for attention, executive, language, memory, motor, and perception domains, while no effects were found with 1 Hz or 5 Hz. Stimulation applied at and 10 and 20 Hz slowed down RTs in attention and perception tasks. No performance enhancement was found. Meta-regression analysis showed that fMRI-guided targeting and short inter-trial intervals are associated with increased disruptive effects with rTMS.

Indexed as

Research DesignTranscranial Magnetic StimulationAttentionBrainCognitionHumansNeuropsychological TestsReaction TimeCognitionMeta-analysisOnline rTMS

Identifiers

PMID31473301
PMCPMC7654714

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.