Trial reportJournal of the American Academy of Child and Adolescent Psychiatry2020
A Randomized Controlled Trial of Interventions for Growth Suppression in Children With Attention-Deficit/Hyperactivity Disorder Treated With Central Nervous System Stimulants.
Trial report in Journal of the American Academy of Child and Adolescent Psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01109849 (Novel Approach to Stimulant Induced Weight Suppression and Its Impact on Growth), which is not on this map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Novel Approach to Stimulant Induced Weight Suppression and Its Impact on Growth
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Effect of methylphenidate on physical growth indicators in children and adolescents with attention-deficit/hyperactivity disorder: a systematic review and meta-analysis.Frontiers in psychiatry · 2026Pooled it
- Growth Trajectories in Stimulant Treated Children and Adolescents: A Qualitative Review of the Literature from Comprehensive Datasets and Registries.Journal of child and adolescent psychopharmacology · 2023Pooled it
- Intentional Discontinuation of Psychostimulants Used to Treat ADHD in Youth: A Review and Analysis.Frontiers in psychiatry · 2021Pooled it
- Micronutrients for ADHD in youth (MADDY) study: comparison of results from RCT and open label extension.European child & adolescent psychiatry · 2024Trial
- Micronutrients for Attention-Deficit/Hyperactivity Disorder in Youths: A Placebo-Controlled Randomized Clinical Trial.Journal of the American Academy of Child and Adolescent Psychiatry · 2022Trial
- Predictors of Changes in Height, Weight, and Body Mass Index After Initiation of Central Nervous System Stimulants in Children with Attention Deficit Hyperactivity Disorder.The Journal of pediatrics · 2022Trial
- Dual Effects of ADHD Pharmacotherapy on Nutrition: A Scoping Review of Appetite, Eating Behavior, and Growth Across the Lifespan.Nutrients · 2026Article
- ADHD and Methylphenidate Use in Prepubertal Children and BMI and Height at Adulthood.JAMA network open · 2026Article
- Duration of ADHD medication treatment among Finnish children and adolescents ‒ a nationwide register study.European child & adolescent psychiatry · 2025Article
- Review
- Methylphenidate Promotes Premature Growth Plate Closure: In Vitro Evidence.International journal of molecular sciences · 2023Article
- In vivo imaging of dopamine D1 receptor and activated microglia in attention-deficit/hyperactivity disorder: a positron emission tomography study.Molecular psychiatry · 2021Article
- Review
- Perspectives in Psychopharmacology.Focus (American Psychiatric Publishing) · 2021Article
- The Impact of Persistent Irritability on the Medication Treatment of Paediatric Attention Deficit Hyperactivity Disorder.Frontiers in psychiatry · 2021Article
- Height, weight, and cardiovascular effects of stimulants on children with brain tumors.Pediatric blood & cancer · 2021Article
Corrections and comments
- Commented on by
Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
Abstract
objectiveTo examine the impact of central nervous system (CNS) stimulants on the growth of children with attention-deficit/hyperactivity disorder (ADHD), and to assess the efficacy and feasibility of weight recovery interventions on growth.
methodA total of 230 children aged 5 to 12 years with ADHD with no history of chronic CNS stimulant use were randomly assigned to receive daily CNS stimulants (78%, primarily osmotic release oral system-methylphenidate [OROS-MPH]) or behavioral treatment (22%) for 30 months. After 6 months, children evidencing a decline in body mass index (BMI) of >0.5 z-units were randomized to 1 of 3 weight recovery treatments (WRTs): monthly monitoring of height/weight (MON) plus continued daily medication; drug holidays (DH) with medication limited to school days; or daily caloric supplementation (CS) with a 150-kcal supplement plus daily medication.
resultsBefore WRT assignment, medication was associated with significant reductions in standardized weight and height (p values <.01). Adherence to CS and DH during WRT was high, with significant increases in daily caloric intake and decreases in weekly medication exposure (p values <.05). Across all WRT participants (n = 71), weight velocity increased significantly after WRT randomization (β
conclusionDrug holidays, caloric supplementation, and increased monitoring all led to increased weight velocity in children taking CNS stimulants, but none led to increased height velocity. CLINICAL TRIAL REGISTRATION INFORMATION: Novel Approach to Stimulant Induced Weight Suppression and Its Impact on Growth; https://clinicaltrials.gov/; NCT01109849.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.