Evidence map›Paper›PMID 31473223›Full record

ArticleBrain research2019

Chronic poly-drug administration damages adult mouse brain neural stem cells.

Erica L McGrath, Caitlin R Schlagal, Ibdanelo Cortez, Tiffany J Dunn, Junling Gao, Robert G Fox, Sonja J Stutz, Yong-Fang Kuo, Jonathan D Hommel, Kelly T Dineley and 3 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Erica L McGrathDepartment of Neuroscience, Cell Biology and Anatomy, University of Texas Medical Branch, Galveston, TX 77555, USA; Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA; Center for Addiction Research, University of Texas Medical Branch, Galveston, TX 77555, USA.
Caitlin R SchlagalDepartment of Neuroscience, Cell Biology and Anatomy, University of Texas Medical Branch, Galveston, TX 77555, USA; Center for Addiction Research, University of Texas Medical Branch, Galveston, TX 77555, USA.
Ibdanelo CortezDepartment of Neurology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Tiffany J DunnDepartment of Neuroscience, Cell Biology and Anatomy, University of Texas Medical Branch, Galveston, TX 77555, USA.
Junling GaoDepartment of Neuroscience, Cell Biology and Anatomy, University of Texas Medical Branch, Galveston, TX 77555, USA.
Robert G FoxCenter for Addiction Research, University of Texas Medical Branch, Galveston, TX 77555, USA.
Sonja J StutzCenter for Addiction Research, University of Texas Medical Branch, Galveston, TX 77555, USA.
Yong-Fang KuoDepartment of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX 77555, USA.
Jonathan D HommelInstitute for Translational Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA; Center for Addiction Research, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Kelly T DineleyCenter for Addiction Research, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Kathryn A CunninghamInstitute for Translational Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA; Center for Addiction Research, University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Bhupendra S KaphaliaDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Ping WuDepartment of Neuroscience, Cell Biology and Anatomy, University of Texas Medical Branch, Galveston, TX 77555, USA; Center for Addiction Research, University of Texas Medical Branch, Galveston, TX 77555, USA. Electronic address: piwu@utmb.edu.
The University of Texas Medical Branch at Galveston · US

Funding

Translational Explorations in Substance Use DisordersT32DA007287 · NIDA · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI Kathryn A. Cunningham, Jonathan Dean Hommel · 1994 to 2026
$4.7M
NIDA NIH HHS T32 DA007287
6 · The paper itself

Abstract

Cocaine and ethanol are two commonly co-abused substances; however, the neuropathology following chronic dual consumption is poorly understood. Neural stem cells (NSCs) are a subpopulation of cells within the adult brain that are integral to brain maintenance and repair making them an appealing target to reverse neurodegeneration associated with abused substances. Yet, knowledge about NSC response to chronic poly-drug administration of ethanol and cocaine is minimal. Here, we developed a novel chronic poly-drug administration paradigm of ethanol and cocaine using a transgenic mouse model to trace endogenous NSC survival and differentiation in three brain regions from both male and female mice. We report significant and distinct patterns of NSC survival and differentiation among brain regions, as well as between sexes. Additionally, poly-drug administration had synergistic effects on NSC survival. Altered cognitive and hedonic behaviors were also observed, however the extent of these behavioral changes was not proportional to the NSC changes. With this mouse model we can effectively examine cognitive and behavioral changes and correlate them with pathological changes in the brain in response to chronic poly-drug administration, which is of great value in understanding the progression of neurodegeneration in polysubstance use disorders and evaluation potential therapeutics on neuroregeneration.

Indexed as

Adult Stem CellsAge FactorsAnimalsBrainCell DifferentiationCocaineDisease Models, AnimalEthanolFemaleHippocampusHumansMaleMiceMice, Inbred C57BLMice, TransgenicNerve RegenerationCocaineEthanolCocaineEthanolNeural stem cellsNeurogenesisPoly-drugTanycyte layer

Identifiers

PMID31473223
PMCPMC9153393
OpenAlexW2970167707

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.