Evidence map›Paper›PMID 31473062›Full record

ArticleNeuron2019

A Rare Mutation of β

Guangsen Shi, Lijuan Xing, David Wu, Bula J Bhattacharyya, Christopher R Jones, Thomas McMahon, S Y Christin Chong, Jason A Chen, Giovanni Coppola, Daniel Geschwind and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 92 citations in OpenAlex.

  1. Trial
  2. Emerging genetics of sleep and circadian disorders.Current opinion in pediatrics · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Prime editing of the βNature communications · 2025
    Article
  7. Review
  8. Article
  9. Rare variants inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. The SIK3-N783Y mutation is associated with the human natural short sleep trait.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. [Behavioral changes of transgenic mice carryingNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024
    Article
  18. Article
  19. Diverse roles of pontine NPS-expressing neurons in sleep regulation.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Guangsen ShiDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.
Lijuan XingDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.
David WuDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.
Bula J BhattacharyyaDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.
Christopher R JonesDepartment of Neurology, University of Utah, Salt Lake City, UT 84108, USA.
Thomas McMahonDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.
S Y Christin ChongDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.
Jason A ChenDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Giovanni CoppolaDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Daniel GeschwindDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Andrew KrystalDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA 94143, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA.
Louis J PtáčekDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: ljp@ucsf.edu.
Ying-Hui FuDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: ying-hui.fu@ucsf.edu.
University of California, San Francisco · USUniversity of California, Los Angeles · USUniversity of Utah · US

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRUMMEL, MATTHEW F · 2003 to 2019
$21.8M
Integrative Center for Neurogenetics and Neurogenomics - OverallP30NS062691 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COPPOLA, GIOVANNI · 2009 to 2018
$7.4M
GENETICS AND MOLECULAR CHARACTERIZATION OF ASPSR01HL059596 · NHLBI · UNIVERSITY OF UTAH · PI PTACEK, LOUIS J. · 1997 to 2012
$5.2M
Investigating the neurocircuitry of sleep duration regulationR01NS104782 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FU, YING-HUI · 2018 to 2022
$3.0M
Probing genetics and biology of human circadian functionR01NS099333 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PTACEK, LOUIS J. · 2017 to 2021
$2.9M
Investigating Genetics of Human Natural Short SleepersR01NS072360 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FU, YING-HUI · 2011 to 2015
$2.2M
NHLBI NIH HHS R01 HL059596NIDDK NIH HHS P30 DK063720NINDS NIH HHS P30 NS062691NINDS NIH HHS R01 NS072360NINDS NIH HHS R01 NS099333NINDS NIH HHS R01 NS104782
6 · The paper itself

Abstract

Sleep is crucial for our survival, and many diseases are linked to long-term poor sleep quality. Before we can use sleep to enhance our health and performance and alleviate diseases associated with poor sleep, a greater understanding of sleep regulation is necessary. We have identified a mutation in the β

Indexed as

AnimalsGene Knock-In TechniquesHumansMiceMutationNeuronsPedigreePontine TegmentumReceptors, Adrenergic, beta-1SleepSleep, REMSleep Wake DisordersWakefulnessADRB1 protein, humanAdrb1 protein, mouseReceptors, Adrenergic, beta-1ADRB1dorsal ponsfamilial natural short sleepsleep duration

Identifiers

PMID31473062
PMCPMC6763376
OpenAlexW2970642842

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.