ArticleBiological psychiatry2020
Atypical Functional Connectivity in Tourette Syndrome Differs Between Children and Adults.
Article in Biological psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Structural and functional alterations in the brain gray matter among Tourette syndrome patients: a multimodal meta-analysis of fMRI and VBM studies.Journal of neurology · 2025Pooled it
- Altered neurodevelopmental trajectories of brain structure in Tourette syndrome and Chronic Tic Disorders.medRxiv : the preprint server for health sciences · 2026Article
- Predictors of Impairment and Self-Concept in Children and Adolescents with Persistent Tic Disorder.Child psychiatry and human development · 2026Article
- Circulating microRNA molecular signatures converge with erythroid phenotypes and iron homeostasis in pediatric tic disorders.Frontiers in psychiatry · 2026Article
- Functional Neuroanatomy of Tics: A Brain Network Perspective.The Psychiatric clinics of North America · 2025Review
- Motor network organization in healthy development and chronic tic disorders.Brain communications · 2025Article
- A critical role of action-related functional networks in Gilles de la Tourette syndrome.Nature communications · 2024Article
- Deep brain stimulation for Tourette's syndrome.The Cochrane database of systematic reviews · 2024Article
- Review of the Brain's Behaviour after Injury and Disease for Its Application in an Agent-Based Model (ABM).Biomimetics (Basel, Switzerland) · 2024Review
- Exploring protocol development: Implementing systematic contextual memory to enhance real-time fMRI neurofeedback.Journal of electrical bioimpedance · 2024Article
- Maturation of large-scale brain systems over the first month of life.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Masked features of task states found in individual brain networks.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Tourette syndrome: clinical features, pathophysiology, and treatment.The Lancet. Neurology · 2023Review
- Mapping a network for tics in Tourette syndrome using causal lesions and structural alterations.Brain communications · 2023Article
- Tourette syndrome research highlights from 2021.F1000Research · 2022Review
- Trends of Tourette Syndrome in children from 2011 to 2021: A bibliometric analysis.Frontiers in behavioral neuroscience · 2022Article
- Basal Ganglia Pathways Associated With Therapeutic Pallidal Deep Brain Stimulation for Tourette Syndrome.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
- Linking irritability and functional brain networks: A transdiagnostic case for expanding consideration of development and environment in RDoC.Neuroscience and biobehavioral reviews · 2021Review
- Impulsive prepotent actions and tics in Tourette disorder underpinned by a common neural network.Molecular psychiatry · 2021Article
- A Comprehensive Review of Tic Disorders in Children.Journal of clinical medicine · 2021Review
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8 authors.
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Abstract
backgroundTourette syndrome (TS) is a neuropsychiatric disorder with symptomatology that typically changes over development. Whether and how brain function in TS also differs across development has been largely understudied. Here, we used functional connectivity magnetic resonance imaging to examine whole-brain functional networks in children and adults with TS.
methodsMultivariate classification methods were used to find patterns among functional connections that distinguish individuals with TS from control subjects separately for children and adults (N = 202). We tested whether the patterns of connections that classify diagnosis in one age group (e.g., children) could classify diagnosis in another age group (e.g., adults). We also tested whether the developmental trajectory of these connections was altered in TS.
resultsDiagnostic classification was successful in children and adults separately but expressly did not generalize across age groups, suggesting that the patterns of functional connections that best distinguished individuals with TS from control subjects were age specific. Developmental patterns among these functional connections used for diagnostic classification deviated from typical development. Brain networks in childhood TS appeared "older" and brain networks in adulthood TS appeared "younger" in comparison with typically developing individuals.
conclusionsOur results demonstrate that brain networks are differentially altered in children and adults with TS. The observed developmental trajectory of affected connections is consistent with theories of accelerated and/or delayed maturation, but may also involve anomalous developmental pathways. These findings further our understanding of neurodevelopmental trajectories in TS and carry implications for future applications aimed at predicting the clinical course of TS in individuals over development.
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