Evidence map›Paper›PMID 31472924›Full record

Observational studyJournal of pediatric surgery2020

Immediate versus silo closure for gastroschisis: Results of a large multicenter study.

Russell B Hawkins, Steven L Raymond, Shawn D St Peter, Cynthia D Downard, Faisal G Qureshi, Elizabeth Renaud, Paul D Danielson, Saleem Islam

Abstract readComparative StudyMulticenter StudyObservational Study
In one paragraph

Observational study in Journal of pediatric surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Short and Medium-term Outcomes of Omphalocele and Gastroschisis: A Survey from a Tertiary Center.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2022
    Article
  9. Article
  10. Article
  11. Gastroschisis: A State-of-the-Art Review.Children (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Russell B HawkinsUniversity of Florida College of Medicine, Department of Surgery, Division of Pediatric Surgery, Gainesville, FL, USA.
Steven L RaymondUniversity of Florida College of Medicine, Department of Surgery, Division of Pediatric Surgery, Gainesville, FL, USA.
Shawn D St PeterChildren's Mercy Hospital, Kansas City, MO, USA.
Cynthia D DownardUniversity of Louisville, Department of Surgery, Division of Pediatric Surgery, Louisville, KY, USA.
Faisal G QureshiUniversity of Texas Southwestern, Department of Surgery, Division of Pediatric Surgery, Dallas, TX, USA.
Elizabeth RenaudAlpert Medical School of Brown University, Department of Surgery, Division of Pediatric Surgery, Providence, RI, USA.
Paul D DanielsonJohns Hopkins All Children's Hospital, St. Petersburg, FL, USA.
Saleem IslamUniversity of Florida College of Medicine, Department of Surgery, Division of Pediatric Surgery, Gainesville, FL, USA. Electronic address: Saleem.Islam@surgery.ufl.edu.

Funding

Molecular Biology in Burns and TraumaT32GM008721 · NIGMS · UNIVERSITY OF FLORIDA · PI Philip A Efron · 1999 to 2026
$5.0M
NIGMS NIH HHS T32 GM008721
6 · The paper itself

Abstract

background/purposeThe optimal method to repair gastroschisis defects continues to be debated. The two primary methods are immediate closure (IC) or silo placement (SP). The purpose of this study was to compare outcomes between each approach using a multicenter retrospective analysis. We hypothesized that patients undergoing SP for ≤5 days would have largely equivalent outcomes compared to IC patients.

methodsGastroschisis patient data were collected over a 7-year period. The cohort was separated into IC and SP groups. The SP group was further stratified based on time to closure (≤5 days, 6-10 days, >10 days). Characteristics and outcomes were compared between groups. Multivariate logistic regression was also performed.

results566 neonates with gastroschisis were identified including 224 patients in the IC group and 337 patients in the SP group. Among SP patients, 130 were closed within 5 days, 140 in 6-10 days, and 57 in >10 days. There were no significant differences in mortality, sepsis, readmission, or days to full enteral feeds between IC patients and SP patients who had a silo ≤5 days. IC patients had a significantly higher incidence of ventral hernias. Multivariate analysis revealed time to closure as a significant independent predictor of length of stay, ventilator duration, time to full enteral feeds, and TPN duration.

conclusionsOur data show largely equivalent outcomes between patients who undergo immediate closure and those who have silos ≤5 days. We propose that closure within 5 days avoids many of the risks commonly attributed to delay in closure. LEVEL OF EVIDENCE: Level II retrospective study.

Indexed as

Digestive System Surgical ProceduresFemaleFollow-Up StudiesGastroschisisHumansInfantInfant, NewbornMalePostoperative ComplicationsRetrospective StudiesTreatment OutcomeGastroschisisImmediate closureSiloVentral hernia

Identifiers

PMID31472924
PMCPMC7731615

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.