ArticleBMC genomics2019
Transcriptome profiling reveals candidate flavonol-related genes of Tetrastigma hemsleyanum under cold stress.
Article in BMC genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.
- A comprehensive review on traditional uses, chemical compositions, pharmacology properties and toxicology of Tetrastigma hemsleyanum.Journal of ethnopharmacology · 2021Pooled it
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- The CsPHL11-CsPAL2 module mediates chitooligosaccharide-induced cold tolerance in cucumber seedlings.Frontiers in plant science · 2026Article
- Exploring metabolite profiles and phenylpropanoids biosynthesis gene expression in Pimpinella anisum L. under water deficit stress.BMC plant biology · 2025Article
- Long-Term Effects of Vegetative-Propagation-Mediated TuMV-ZR Transmission on Yield, Quality, and Stress Resistance inPathogens (Basel, Switzerland) · 2025Article
- Flavonoids as key players in cold tolerance: molecular insights and applications in horticultural crops.Horticulture research · 2025Article
- Deciphering the molecular signatures of tropicalFrontiers in plant science · 2025Article
- Physiological and molecular regulatory mechanism of flavonoid metabolite biosynthesis during low temperature adaptation in Lavandula angustifolia Mill.BMC plant biology · 2024Article
- Abiotic stress-induced changes in Tetrastigma hemsleyanum: insights from secondary metabolite biosynthesis and enhancement of plant defense mechanisms.BMC plant biology · 2024Article
- Mechanisms and Impact of Rhizosphere Microbial Metabolites on Crop Health, Traits, Functional Components: A Comprehensive Review.Molecules (Basel, Switzerland) · 2024Review
- Flavonoid Synthesis Pathway Response to Low-Temperature Stress in a Desert Medicinal Plant,Genes · 2024Article
- Effects of Low-Temperature Stress on Physiological Characteristics and Microstructure of Stems and Leaves ofPlants (Basel, Switzerland) · 2024Article
- Integrated Transcriptomic and Proteomic Analysis Reveals Molecular Mechanisms of the Cold Stress Response during the Overwintering Period in Blueberries (Plants (Basel, Switzerland) · 2024Article
- Integrated transcriptomic and metabolomic analysis provides insights into cold tolerance in lettuce (Lactuca sativa L.).BMC plant biology · 2024Article
- Differential effects of winter cold stress on soil bacterial communities, metabolites, and physicochemical properties in two varieties ofMicrobiology spectrum · 2024Article
- Integrated transcriptomic and WGCNA analyses reveal candidate genes regulating mainly flavonoid biosynthesis in Litsea coreana var. sinensis.BMC plant biology · 2024Article
- Full-length transcriptome reveals the pivotal role of ABA and ethylene in the cold stress response ofFrontiers in plant science · 2024Article
- Transcriptomic responses to cold stress inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2023Article
- Insights into Metabolic Engineering of Bioactive Molecules inCurrent genomics · 2023Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundTetrastigma hemsleyanum Diels et Gilg is a valuable medicinal herb, whose main bioactive constituents are flavonoids. Chilling sensitivity is the dominant environmental factor limiting growth and development of the plants. But the mechanisms of cold sensitivity in this plant are still unclear. Also, not enough information on genes involved in flavonoid biosynthesis in T. hemsleyanum is available to understand the mechanisms of its physiological and pharmaceutical effects.
resultsThe electrolyte leakage, POD activity, soluble protein, and MDA content showed a linear sustained increase under cold stress. The critical period of cold damage in T. hemsleyanum was from 12 h to 48 h. Expression profiles revealed 18,104 differentially expressed genes (DEGs) among these critical time points. Most of the cold regulated DEGs were early-response genes. A total of 114 unigenes were assigned to the flavonoid biosynthetic pathway. Fourteen genes most likely to encode flavonoid biosynthetic enzymes were identified. Flavonols of T. hemsleyanum might play a crucial role in combating cold stress. Genes encoding PAL, 4CL, CHS, ANR, FLS, and LAR were significantly up-regulated by cold stress, which could result in a significant increase in crucial flavonols (catechin, epicatechin, rutin, and quercetin) in T. hemsleyanum.
conclusionsOverall, our results show that the expression of genes related to flavonol biosynthesis as well as flavonol content increased in T. hemsleyanum under cold stress. These findings provide valuable information regarding the transcriptome changes in response to cold stress and give a clue for identifying candidate genes as promising targets that could be used for improving cold tolerance via molecular breeding. The study also provides candidate genes involved in flavonoid biosynthesis and may be useful for clarifying the biosynthetic pathway of flavonoids in T. hemsleyanum.
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