Evidence map›Paper›PMID 31472330›Full record

ArticleNeuroImage. Clinical2019

Sexual trauma history is associated with reduced orbitofrontal network strength in substance-dependent women.

Tasha Poppa, Vita Droutman, Hortensia Amaro, David Black, Inna Arnaudova, John Monterosso

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Neural Underpinnings of Social Stress in Substance Use Disorders.Current topics in behavioral neurosciences · 2022
    Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Tasha PoppaDepartment of Psychology, University of Southern California, Los Angeles, United States of America. Electronic address: npoppa@usc.edu.
Vita DroutmanDepartment of Psychology, University of Southern California, Los Angeles, United States of America.
Hortensia AmaroHerbert Wertheim College of Medicine, Robert Stempel College of Public Health and Social Work, Florida International University, Los Angeles, United States of America.
David BlackDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, United States of America.
Inna ArnaudovaDepartment of Psychiatry, University of California, Los Angeles, United States of America.
John MonterossoDepartment of Psychology, University of Southern California, Los Angeles, United States of America.
University of Southern California · USFlorida International University · USUniversity of California, Los Angeles · US

Funding

The Effects of Social Networks on Women's Substance Use Disorder Recovery OutcomesR01DA038648 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AMARO, HORTENSIA D., BLACK, DAVID SCOTT · 2015 to 2018
$2.3M
NIDA NIH HHS R01 DA038648
6 · The paper itself

Abstract

aimSubstance use disorders (SUDs) are highly comorbid with post-traumatic stress disorder (PTSD). PTSD-SUD comorbidity is associated with greater functional impairments and relapse risk. Women with SUDs experience markedly higher rates of trauma and PTSD compared to men with SUDs, particularly due to sexual and domestic abuse. Despite the strong association between trauma exposure and SUDs, the neurobiological correlates are understudied, particularly among females with SUDs. However, there is indication of abnormal somatic and interoceptive processing in women with PTSD. The present study examines interoception-linked differences in intrinsic brain networks in a group of women with SUDs and varying histories of trauma exposure, some of whom have a current PTSD diagnosis.

methodsPre-intervention data were analyzed from a subset (N = 43) of women in SUD residential treatment recruited for a mindfulness-based intervention efficacy clinical trial. Participants diagnosed with PTSD (n = 14) or not (n = 29) performed a task which involved attending to the somatic and visceral sensations of the breathing cycle (interoception) while undergoing a functional MRI (fMRI) scan. FMRI analysis employed independent components analysis and dual regression. First, we assessed differences in functional connectivity of interoception-modulated functional networks among those with and without PTSD. Second, we tested associations between network strength and lifetime sexual violence exposure across all participants on networks that showed significant group differences.

resultsPTSD diagnosis was associated with reduced functional connectivity of an orbitofrontal network with the precuneus, mid-posterior insula, lateral prefrontal cortex and angular gyrus. OFC network strength was inversely associated with sexual violence exposure over-and-above the contribution of PTSD status alone.

conclusionsOur findings provide a novel network-level account of brain activity associated with PTSD among women with SUDs, which may inform treatment response in this subpopulation.

Indexed as

Sex OffensesAdultBrainBrain MappingComorbidityCrime VictimsFemaleHumansInteroceptionMagnetic Resonance ImagingMiddle AgedStress Disorders, Post-TraumaticSubstance-Related DisordersAddictionFemaleInsulaInteroceptionOrbitofrontal cortexPost-traumatic stress disorder

Identifiers

PMID31472330
PMCPMC6728879
OpenAlexW2966757525

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.