Evidence map›Paper›PMID 31472301›Full record

ArticleBone2019

Validation of the FRAiL model to predict non-vertebral and hip fractures in nursing home residents.

Sarah D Berry, Andrew R Zullo, Tingting Zhang, Yoojin Lee, Kevin W McConeghy, Douglas P Kiel

Open access · greenAbstract read
In one paragraph

Article in Bone, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. The Effect of Fall Biomechanics on Risk for Hip Fracture in Older Adults: A Cohort Study of Video-Captured Falls in Long-Term Care.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020
    Article
  3. Editorial: Old Bones.The journal of nutrition, health & aging · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sarah D BerryHebrew SeniorLife, Hinda and Arthur Marcus Institute for Aging Research, Boston, MA, United States of America; Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, MA, United States of America. Electronic address: sarahberry@hsl.harvard.edu.
Andrew R ZulloBrown University School of Public Health, Providence, RI, United States of America; Center of Innovation in Long-Term Services and Supports, Providence Veterans Affairs Medical Center, Providence, RI, United States of America.
Tingting ZhangBrown University School of Public Health, Providence, RI, United States of America.
Yoojin LeeBrown University School of Public Health, Providence, RI, United States of America.
Kevin W McConeghyBrown University School of Public Health, Providence, RI, United States of America; Center of Innovation in Long-Term Services and Supports, Providence Veterans Affairs Medical Center, Providence, RI, United States of America.
Douglas P KielHebrew SeniorLife, Hinda and Arthur Marcus Institute for Aging Research, Boston, MA, United States of America; Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, MA, United States of America.
Brown University · USBeth Israel Deaconess Medical Center · US

Funding

VARIATIONS IN LIFE'S FINAL CHAPTERP01AG027296 · NIA · BROWN UNIVERSITY · PI AMAL N. TRIVEDI · 2007 to 2026
$38.9M
Develop Patient Centered Outcomes Scholars for Comparative Effectiveness ResearchK12HS022998 · AHRQ · BROWN UNIVERSITY · PI TRIKALINOS, THOMAS · 2014 to 2018
$3.4M
A Clinical Prediction Tool to Guide Treatment of Osteoporosis in the Nursing HomeR01AG045441 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI BERRY, SARAH DYER · 2014 to 2017
$1.7M
AHRQ HHS K12 HS022998NIA NIH HHS P01 AG027296NIA NIH HHS R01 AG045441
6 · The paper itself

Abstract

objectiveTools were unavailable to assess fracture risk in nursing homes (NH); therefore, we developed the Fracture Risk Assessment in Long term care (FRAiL) model. The objective of this validation study was to assess the performance of the FRAiL model to predict 2-year risk of non-vertebral and hip fractures in a separate large cohort of NH residents.

methodsThis retrospective cohort study included most long-stay NH residents in the United States (N = 896,840). Hip and non-vertebral fractures were identified using Medicare claims. The Minimum Data Set (MDS) was used to identify characteristics from the original FRAiL model. Multivariable competing risk regression was used to model risk of fracture.

resultsMean age was 83.8 years (±8.2 years) and 70.7% were women. Over a mean follow-up of 1.52 years (SD 0.65), 41,531 residents (4.6%) were hospitalized with non-vertebral fracture (n = 30,356 hip fractures). In the fully adjusted model, 14/15 model characteristics remained significant predictors of non-vertebral fracture. Female sex (HR = 1.55, 95% CI 1.52, 1.59), wandering (HR = 1.30, 95% CI 1.26, 1.34), and falls (HR = 1.28, 95% CI 1.26, 1.31) were strongly associated with non-vertebral fracture rate. Total dependence in ADLs (versus independence) was associated with a decrease in non-vertebral fracture rate (HR = 0.57, 95% CI 0.52, 0.64). Discrimination was moderate in men (C-index = 0.68 for hip, 0.66 for non-vertebral) and women (C-index = 0.68 for hip, 0.65 for non-vertebral), and calibration was excellent.

conclusionsOur model comprised entirely from routinely collected data was able to identify NH residents at greatest risk for non-vertebral fracture.

Indexed as

AgedAged, 80 and overCalibrationFemaleHip FracturesHumansMaleMultivariate AnalysisNursing HomesRetrospective StudiesRisk FactorsHip fractureNon-vertebral fractureNursing homePrediction modelRisk factors

Identifiers

PMID31472301
PMCPMC6823926
OpenAlexW2970681667

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.